The effect of cyclodextrins on the in vitro and in vivo properties of insulin-loaded poly (D,L-lactic-co-glycolic acid) microspheres

被引：0
|
作者：
Rodrigues, JM
Lima, KD
Jensen, CED
de Aguiar, MMG
Cunha, AD
机构：
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, Brazil
[2] Univ Fed Minas Gerais, Pharmaceut Technol Lab, Belo Horizonte, MG, Brazil
来源：
ARTIFICIAL ORGANS | 2003年 / 27卷 / 05期
关键词：
insulin; diabetes; cyclodextrins; microspheres; pulmonary administration; powder inhalation;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this work we describe the development and characterization of a new formulation of insulin (INS). Insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability being available as a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. The complex INS : CD was encapsulated into microspheres in order to obtain particles with an average diameter between 2 and 6 mum. This system was able to induce significant reduction of the plasma glucose level in two rodent models, normal mice and diabetic rats, after intratracheal administration.
引用
收藏
页码：492 / 497
页数：6
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