The effect of cyclodextrins on the in vitro and in vivo properties of insulin-loaded poly (D,L-lactic-co-glycolic acid) microspheres

被引：0
|
作者：
Rodrigues, JM
Lima, KD
Jensen, CED
de Aguiar, MMG
Cunha, AD
机构：
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, Brazil
[2] Univ Fed Minas Gerais, Pharmaceut Technol Lab, Belo Horizonte, MG, Brazil
来源：
ARTIFICIAL ORGANS | 2003年 / 27卷 / 05期
关键词：
insulin; diabetes; cyclodextrins; microspheres; pulmonary administration; powder inhalation;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this work we describe the development and characterization of a new formulation of insulin (INS). Insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability being available as a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. The complex INS : CD was encapsulated into microspheres in order to obtain particles with an average diameter between 2 and 6 mum. This system was able to induce significant reduction of the plasma glucose level in two rodent models, normal mice and diabetic rats, after intratracheal administration.
引用
收藏
页码：492 / 497
页数：6
相关论文
共 50 条
  • [1] Preparation and in vitro release of DNA-loaded poly(D,L-lactic-co-glycolic acid) microspheres
    Son, HJ
    Kim, JS
    POLYMER-KOREA, 2005, 29 (01) : 69 - 73
  • [2] Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo
    Newman, KD
    Elamanchili, P
    Kwon, GS
    Samuel, J
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 60 (03): : 480 - 486
  • [3] Preparation and characterisation of poly(D,L-lactic-co-glycolic acid) microspheres containing desferrioxamine
    Schlicher, EJAM
    Postma, NS
    Zuidema, J
    Talsma, H
    Hennink, WE
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 153 (02) : 235 - 245
  • [4] Poly(D, L-lactic-co-glycolic acid)-based microspheres loaded with camphor regulate skeletal muscle atrophy
    Jang, Hyun Joo
    Han, Chung Su
    Kwon, Suhyun
    Kwon, Seung Hae
    Ko, Solomon
    Kim, Jae Hyuk
    Yoon, Myeong Sik
    Baek, Suji
    Lee, Kang Pa
    MACROMOLECULAR RESEARCH, 2024, : 971 - 979
  • [5] The use of poly(D,L-lactic-co-glycolic) acid microspheres in the treatment of allergic disease
    Reisacher, William R.
    Liotta, Dara
    CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY, 2011, 19 (03): : 188 - 192
  • [6] PROPERTIES OF MULTIPHASE MICROSPHERES OF POLY(D,L-LACTIC-CO-GLYCOLIC ACID) PREPARED BY A POTENTIOMETRIC DISPERSION TECHNIQUE
    ODONNELL, PB
    IWATA, M
    MCGINITY, JW
    JOURNAL OF MICROENCAPSULATION, 1995, 12 (02) : 155 - 163
  • [7] Poly(D,L-lactic-co-glycolic acid) microspheres for sustained delivery and stabilization of camptothecin
    Ertl, B
    Platzer, P
    Wirth, M
    Gabor, F
    JOURNAL OF CONTROLLED RELEASE, 1999, 61 (03) : 305 - 317
  • [8] Biocompatibility and biodegradation of poly(D,L-lactic-co-glycolic acid) 90/10: In vitro and in vivo assays
    Yang, Ning
    Li, Yue
    Gong, Yongtai
    Liu, Wei
    Xue, Hongjie
    Zhao, Jiyi
    Shao, Qun
    Li, Weimin
    Iranian Polymer Journal (English Edition), 2009, 18 (02): : 129 - 137
  • [9] Biocompatibility and Biodegradation of Poly(D,L-lactic-co-glycolic acid) 90/10: In Vitro and In Vivo Assays
    Yang, Ning
    Li, Yue
    Gong, Yongtai
    Liu, Wei
    Xue, Hongjie
    Zhao, Jiyi
    Shao, Qun
    Li, Weimin
    IRANIAN POLYMER JOURNAL, 2009, 18 (02) : 129 - 137
  • [10] BIODEGRADATION AND TISSUE REACTION TO INTRAVITREOUS BIODEGRADABLE POLY(D,L-LACTIC-CO-GLYCOLIC) ACID MICROSPHERES
    GIORDANO, GG
    CHEVEZBARRIOS, P
    REFOJO, MF
    GARCIA, CA
    CURRENT EYE RESEARCH, 1995, 14 (09) : 761 - 768
12345