Antimicrobial Actions and Applications of Chitosan

被引：416

作者：

Ke, Cai-Ling ^{[1
]}

Deng, Fu-Sheng ^{[1
]}

Chuang, Chih-Yu ^{[1
]}

Lin, Ching-Hsuan ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Life Sci, Dept Biochem Sci & Technol, Taipei 10617, Taiwan

来源：

POLYMERS | 2021年 / 13卷 / 06期

关键词：

chitosan; antimicrobial activity; physicochemical characteristics; nanoparticles; films; MOLECULAR-WEIGHT CHITOSAN; WATER-SOLUBLE CHITOSAN; CELL-WALL POROSITY; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL ACTIVITY; BIOMEDICAL APPLICATIONS; CARBOXYMETHYL CHITOSAN; ESCHERICHIA-COLI; CANDIDA-ALBICANS; PLASMA-MEMBRANE;

D O I：

10.3390/polym13060904

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the antimicrobial activity of chitosan varies, because this activity is associated with its physicochemical characteristics and depends on the type of microorganism. In this review article, the fundamental properties, modes of antimicrobial action, and antimicrobial effects-related factors of chitosan are discussed. We further summarize how microorganisms genetically respond to chitosan. Finally, applications of chitosan-based biomaterials, such as nanoparticles and films, in combination with current clinical antibiotics or antifungal drugs, are also addressed.

引用

页数：21

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