Inhibition of Porphyromonas gingivalis Biofilm by Oxantel

被引：13

作者：

Dashper, Stuart ^{[1
]}

Ang, Ching-Seng ^{[1
]}

Liu, Sze Wei ^{[1
]}

Paolini, Rita ^{[1
]}

Veith, Paul ^{[1
]}

Reynolds, Eric ^{[1
]}

机构：

[1] Univ Melbourne, CRC Oral Hlth Sci, Melbourne Dent Sch, Inst Bio21, Melbourne, Vic 3010, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 03期

基金：

英国医学研究理事会;

关键词：

HELICOBACTER-PYLORI; FUMARATE REDUCTASE; THIABENDAZOLE; PROTEIN;

D O I：

10.1128/AAC.00946-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.

引用

页码：1311 / 1314

页数：4

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