A novel toxin variant from the Androctonus australis hector scorpion venom selectively activates Kv7.4 channel

被引：0
|
作者：
Landoulsi, Z. [1 ]
Miceli, F. [2 ]
Palmese, A. [3 ]
Amoresano, A. [3 ]
Marino, G. [3 ]
El Ayeb, M. [1 ]
Taglialatela, M. [2 ,4 ,5 ]
Benkhalifa, R. [1 ]
机构：
[1] Univ Tunis El Manor, Inst Pasteur Tunis, Lab Venins & Mol Therapeut, Tunis, Tunisia
[2] Univ Naples Federico II, Div Pharmacol, Dept Neurosci, Naples, Italy
[3] Univ Naples Federico II, Dept Chem Sci, Naples, Italy
[4] Univ Molise, Dept Med & Hlth Sci, Campobasso, Italy
[5] Univ Basque Country, CSIC, Unidad Biofis, Leioa, Spain
来源：
TOXICON | 2014年 / 91卷
关键词：
D O I：
10.1016/j.toxicon.2014.08.031
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
23
引用
收藏
页码：174 / 174
页数：1
相关论文
共 40 条
  • [21] MONOCLONAL-ANTIBODIES TO TOXIN-II FROM THE SCORPION ANDROCTONUS-AUSTRALIS-HECTOR - FURTHER CHARACTERIZATION OF EPITOPE SPECIFICITIES AND NEUTRALIZING CAPACITIES
    YAHI, N
    DEVAUX, C
    MANSUELLE, P
    DEFENDINI, ML
    GRANIER, C
    TOXICON, 1992, 30 (07) : 723 - 731
  • [22] CRYSTALLIZATION AND PRELIMINARY-X-RAY STUDY OF AAH IT2, AN INSECT-SPECIFIC TOXIN FROM THE SCORPION ANDROCTONUS-AUSTRALIS HECTOR
    ABERGEL, C
    LORET, E
    ROCHAT, H
    FONTECILLACAMPS, JC
    JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (03) : 637 - 638
  • [23] CRYSTAL-STRUCTURE OF TOXIN-II FROM THE SCORPION ANDROCTONUS-AUSTRALIS HECTOR REFINED AT 1-CENTER-DOT-3 ANGSTROM RESOLUTION
    HOUSSET, D
    HABERSETZERROCHAT, C
    ASTIER, JP
    FONTECILLACAMPS, JC
    JOURNAL OF MOLECULAR BIOLOGY, 1994, 238 (01) : 88 - 103
  • [24] EFFECTS OF TOXIN-II FROM THE SCORPION ANDROCTONUS-AUSTRALIS HECTOR ON SODIUM CURRENT IN NEURO-BLASTOMA CELLS AND THEIR MODULATION BY OLEIC-ACID
    JOURDON, P
    BERWALDNETTER, Y
    HOUZET, E
    COURAUD, F
    DUBOIS, JM
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1989, 16 (06): : 351 - 356
  • [25] A novel K+ channel blocking toxin from Tityus discrepans scorpion venom
    D'Suze, G
    Zamudio, F
    Gómez-Lagunas, F
    Possani, LD
    FEBS LETTERS, 1999, 456 (01) : 146 - 148
  • [26] AN ANTIINSECT TOXIN PURIFIED FROM THE SCORPION ANDROCTONUS-AUSTRALIS HECTOR ALSO ACTS ON THE ALPHA-SITES AND BETA-SITES OF THE MAMMALIAN SODIUM-CHANNEL - SEQUENCE AND CIRCULAR-DICHROISM STUDY
    LORET, EP
    MARTINEAUCLAIRE, MF
    MANSUELLE, P
    SAMPIERI, F
    GRANIER, C
    ROCHAT, H
    BIOCHEMISTRY, 1991, 30 (03) : 633 - 640
  • [27] ACTIONS OF INSECT TOXIN AND OTHER TOXINS DERIVED FROM THE VENOM OF THE SCORPION ANDROCTONUS-AUSTRALIS ON ISOLATED GIANT-AXONS OF THE COCKROACH (PERIPLANETA-AMERICANA)
    PELHATE, M
    ZLOTKIN, E
    JOURNAL OF EXPERIMENTAL BIOLOGY, 1982, 97 (APR): : 67 - 77
  • [28] Molecular cloning of a novel putative potassium channel-blocking neurotoxin from the venom of the North African scorpion, Androctonus amoreuxi
    Chen, TB
    Walker, B
    Zhou, M
    Shaw, C
    PEPTIDES, 2005, 26 (05) : 731 - 736
  • [29] CHANGES IN NA CHANNEL PROPERTIES OF FROG AND RAT SKELETAL-MUSCLES INDUCED BY THE AAH-II TOXIN FROM THE SCORPION ANDROCTONUS-AUSTRALIS
    DUVAL, A
    MALECOT, CO
    PELHATE, M
    ROCHAT, H
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1989, 415 (03): : 361 - 371
  • [30] INVOLVEMENT OF OXIDATIVE STRESS IN SCORPION VENOM FRACTION V FROM ANDROCTONUS AUSTRALIS HECTOR INDUCED APOPTOSIS IN NON-SMALL CELL LUNG CARCINOMA NCL-H358 CELLS
    Bechohra, L.
    Zerrouti, K.
    Khemili, D.
    Laraba-Djebari, F.
    Hammoudi-Triki, D.
    TOXICON, 2016, 116 : 82 - 82
1234