Design and Synthesis of 3′-Fluoropenciclovir Analogues as Antiviral Agents

被引：3
|
作者：
Choi, Myung-Hee [1 ]
Lee, Chong-Kyo [2 ]
Kim, Hee-Doo [1 ]
机构：
[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea
[2] Res Inst Chem Technol, Taejon 305606, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 02期
关键词：
Antiviral; Fluorine switch; Penciclovir; 3 '-Fluoropenciclovir; OPEN-CHAIN ANALOGS; NUCLEOSIDES; NEPLANOCIN;
D O I：
10.1007/s12272-010-0202-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
引用
收藏
页码：197 / 202
页数：6
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