Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells

被引：0
|
作者：
Li Cong-Xin [1 ]
Chen Xiao-Fang [1 ]
Wang Peng-Ye [1 ]
Wang Wei-Chi [1 ]
机构：
[1] Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, Beijing 100190, Peoples R China
来源：
CHINESE PHYSICS LETTERS | 2010年 / 27卷 / 02期
关键词：
ACTIVATED CALCIUM-CHANNEL; OSCILLATIONS; MODEL; SENSOR; STORE; STIM1;
D O I：
10.1088/0256-307X/27/2/028701
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (k(soc)). When k(soc) is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after k(soc) passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.
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页数：4
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