Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells

被引：0
|
作者：
Li Cong-Xin [1 ]
Chen Xiao-Fang [1 ]
Wang Peng-Ye [1 ]
Wang Wei-Chi [1 ]
机构：
[1] Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, Beijing 100190, Peoples R China
来源：
CHINESE PHYSICS LETTERS | 2010年 / 27卷 / 02期
关键词：
ACTIVATED CALCIUM-CHANNEL; OSCILLATIONS; MODEL; SENSOR; STORE; STIM1;
D O I：
10.1088/0256-307X/27/2/028701
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (k(soc)). When k(soc) is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after k(soc) passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Single channel properties and regulated expression of Ca2+ release-activated Ca2+ (CRAC) channels in human T cells
    Fomina, AF
    Fanger, CM
    Kozak, JA
    Cahalan, MD
    JOURNAL OF CELL BIOLOGY, 2000, 150 (06): : 1435 - 1444
  • [2] CRAC in a patch:: Single channel recording of a store-operated Ca2+ channel in Jurkat T cells.
    Cahalan, MD
    Kerschbaum, HH
    BIOPHYSICAL JOURNAL, 2000, 78 (01) : 131A - 131A
  • [3] Role of a Ca2+ entry channel, the CRAC channel, in cell function
    Hogan, P. G.
    Feske, S.
    Gwack, Y.
    Prakriya, M.
    Rao, A.
    JOURNAL OF NEUROCHEMISTRY, 2007, 102 : 238 - 238
  • [4] Interference with Ca2+ release activated Ca2+ (CRAC) channel function delays T-cell arrest in vivo
    Waite, Janelle C.
    Vardhana, Santosh
    Shaw, Patrick J.
    Jang, Jung-Eun
    McCarl, Christie-Ann
    Cameron, Thomas O.
    Feske, Stefan
    Dustin, Michael L.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (12) : 3343 - 3354
  • [5] Inhibition of Ca2+-Release-Activated Ca2+ Channel (CRAC) and K+ Channels by Curcumin in Jurkat-T Cells
    Shin, Dong Hoon
    Seo, Eun Yeong
    Pang, Bo
    Nam, Joo Hyun
    Kim, Hyang Sun
    Kim, Woo Kyung
    Kim, Sung Joon
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 (02) : 144 - 154
  • [6] CRAC channels and Ca2+ signaling in mast cells
    Di Capite, Joseph
    Parekh, Anant B.
    IMMUNOLOGICAL REVIEWS, 2009, 231 : 45 - 58
  • [7] A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
    Feske, S
    Prakriya, M
    Rao, A
    Lewis, RS
    JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (05): : 651 - 662
  • [8] Defect in CRAC Ca2+ channel function associated with altered K+ channel Gating properties in T cells from immunodeficient patients
    Feske, S
    Prakriya, M
    Rao, A
    CLINICAL IMMUNOLOGY, 2005, 115 : S246 - S246
  • [9] Defect in CRAC Ca2+ channel function associated with altered K+ channel gating properties in T cells from immunodeficient patients
    Feske, S
    Prakriya, M
    Lewis, RS
    Rao, A
    FASEB JOURNAL, 2005, 19 (05): : A1163 - A1163
  • [10] DIFFERENTIAL EFFECTS OF CYCLOSPORINE A AND CRAC INHIBITOR ON CA2+ SIGNALING PATHWAYS IN HUMAN CD4+T CELLS AND REGULATORY T CELLS
    Jin, Sue
    Olson, Pamela
    DeMartino, Julie
    Thomas, Dori A.
    INFLAMMATION RESEARCH, 2012, 61 : S16 - S16
12345