MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

被引：105
|
作者：
Liu, Sen [1 ,2 ,3 ]
Fan, Min [1 ,2 ,3 ]
Zheng, Qiang [1 ,2 ,3 ]
Hao, Shengwei [1 ,2 ,3 ]
Yang, Longjun [4 ]
Xia, Qingrong [5 ]
Qi, Congcong [6 ]
Ge, Jinfang [1 ,2 ,3 ]
机构：
[1] Anhui Med Univ, Sch Pharm, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Key Lab Antiinflammatory & Immune Med, Minist Educ, Hefei, Peoples R China
[3] Anhui Inst Innovat Drugs, Anhui Prov Lab Inflammatory & Immun Dis, Hefei, Peoples R China
[4] Anhui Med Univ, Chaohu Clin Med Coll, Hefei, Peoples R China
[5] Hefei Fourth Peoples Hosp, Dept Pharm, Hefei, Peoples R China
[6] Fudan Univ, Dept Lab Anim Sci, 130 Dong An Rd, Shanghai 200032, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 148卷
基金：
中国国家自然科学基金;
关键词：
miRNA; Alzheimer 's disease; Serum markers; Diagnostics; Therapeutics; NEURONS CELL APOPTOSIS; TAU PHOSPHORYLATION; NEUROFIBRILLARY TANGLES; CEREBROSPINAL-FLUID; EXPRESSION; BIOMARKERS; PROTEIN; INFLAMMATION; INVOLVEMENT; IMPAIRMENT;
D O I：
10.1016/j.biopha.2022.112681
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Alzheimer's disease (AD) is the most common neurodegenerative disease, with cognitive decline as the primary clinical feature. According to epidemiological statistics, 50 million people worldwide are currently affected by Alzheimer's disease. Although new drugs such as aducanumab have been approved for use in the treatment of AD, none of them have reversed the progression of AD. MicroRNAs (miRNAs) are small molecule RNAs that exert their biological functions by regulating the expression of intracellular proteins, and differential abundance and varieties are found between the central and peripheral tissues of AD patients and healthy controls. This article will summarise the changes of miRNAs in the AD process, and the potential role of diagnostic markers and therapeutic targets in AD will be explored.
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页数：9
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