Macrophage Extracellular Traps: Current Opinions and the State of Research regarding Various Diseases

被引：20
|
作者：
Weng, Weizhen [1 ]
Hu, Zuoyu [1 ]
Pan, Yunfeng [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Internal Med, Div Rheumatol, Guangzhou 510630, Peoples R China
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2022年 / 2022卷
基金：
中国国家自然科学基金;
关键词：
NEUTROPHIL;
D O I：
10.1155/2022/7050807
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophages are an important component of the human immune system and play a key role in the immune response, which can protect the body against infection and regulate the development of tissue inflammation. Some studies found that macrophages can produce extracellular traps (ETs) under various conditions of stimulation. ETs are web-like structures that consist of proteins and DNA. ETs are thought to immobilize and kill microorganisms, as well as play an important role in tissue damage, inflammatory progression, and autoimmune diseases. In this review, the structure, identification, mechanism, and research progress of macrophage extracellular traps (METs) in related diseases are reviewed.
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页数：10
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