Nesfatin-1/Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, an Invasion in Bladder Cancer

被引：20
|
作者：
Liu, Guang-Ming [1 ]
Xu, Zi-Qiang [1 ]
Ma, Hong-Shun [1 ]
机构：
[1] Tianjin First Ctr Hosp, Dept Urol, 24 Fukang Rd, Tianjin 300192, Peoples R China
来源：
DISEASE MARKERS | 2018年 / 2018卷
关键词：
NUCLEOBINDIN; 2; NESFATIN-1; CARCINOMA; NUCB2; NUCB2/NESFATIN-1; IDENTIFICATION; STATISTICS; EXPRESSION; GROWTH;
D O I：
10.1155/2018/4272064
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bladder cancer using immunohistochemistry and observed that its high expression was associated with recurrence and metastasis. In addition, the transwell assay and wound healing assay showed that cell migration and invasion were decreased with NUCB2 knockdown in T24 and 5637 cells. In vivo, tumor growth and metastasis were inhibited with shRNA treatment in T24 cells. Those results showed that NUCB2 played an important role in bladder cancer and could be considered a potent prognostic factor in bladder cancer.
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页数：9
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