Epigenetics in the pathogenesis of diabetic nephropathy

被引：78
|
作者：
Li, Xue [1 ]
Lu, Lihong [1 ]
Hou, Wenting [1 ]
Huang, Ting [1 ]
Chen, Xiangyuan [1 ]
Qi, Jie [2 ]
Zhao, Yanjun [3 ]
Zhu, Minmin [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll, Dept Anesthesiol,Dept Oncol, Shanghai 200032, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Anesthesiol, Sch Med, Shanghai 200080, Peoples R China
[3] Fudan Univ, Eye & ENT Hosp, Dept Anesthesiol, Shanghai 200031, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2022年 / 54卷 / 02期
基金：
美国国家科学基金会;
关键词：
diabetes; diabetic nephropathy; epigenetics; metabolic memory; LONG NONCODING RNA; GLYCATION END-PRODUCTS; HISTONE DEACETYLASE; GENE-EXPRESSION; HYPERGLYCEMIC MEMORY; METABOLIC-REGULATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; PODOCYTE INJURY; DNA METHYLATION;
D O I：
10.3724/abbs.2021016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an important impact on the development of DN through a variety of mechanisms, and promotes the generation and maintenance of metabolic memory, thus ultimately leading to a poor prognosis. In this review we discuss the methylation of DNA, modification of histone, and regulation of non-coding RNA involved in the progress of cell dysfunction, inflammation and fibrosis in the kidney, which ultimately lead to the deterioration of DN.
引用
收藏
页码：163 / 172
页数：10
相关论文
共 50 条
  • [21] Metalloproteinases in the pathogenesis of diabetic nephropathy
    Suzuki, D
    NEPHRON, 1998, 80 (02): : 125 - 133
  • [22] THOUGHTS ON THE PATHOGENESIS OF DIABETIC NEPHROPATHY
    MAUER, SM
    STEFFES, MW
    AZAR, S
    BROWN, DM
    DIABETES & METABOLISM, 1988, 14 (2BIS): : 206 - 206
  • [23] Exploring the pathogenesis and treatment of IgA nephropathy based on epigenetics
    Zhang, Yunfan
    Yang, Huanhuan
    Jiang, Ming
    Nie, Xiaojing
    EPIGENOMICS, 2023, 15 (19) : 1017 - 1026
  • [24] Diabetic nephropathy: The regulatory interplay between epigenetics and microRNAs
    Sankrityayan, Himanshu
    Kulkarni, Yogesh A.
    Gaikwad, Anil Bhanudas
    PHARMACOLOGICAL RESEARCH, 2019, 141 : 574 - 585
  • [25] THE ROLE OF UROKINASE IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY
    GRANT, PJ
    STICKLAND, MH
    RAYNER, HC
    CREIGHTONKEMPSFORD, L
    GAFFNEY, PJ
    THROMBOSIS AND HAEMOSTASIS, 1993, 69 (06) : 829 - 829
  • [26] Pathogenesis of diabetic nephropathy: A radical approach
    Salahudeen, AK
    Kanji, V
    Reckelhoff, JF
    Schmidt, AM
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1997, 12 (04) : 664 - 668
  • [27] The RAAS in the pathogenesis and treatment of diabetic nephropathy
    Piero Ruggenenti
    Paolo Cravedi
    Giuseppe Remuzzi
    Nature Reviews Nephrology, 2010, 6 : 319 - 330
  • [28] ARE PLATELETS INVOLVED IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY
    HOPPER, AH
    TINDALL, H
    BARKER, MJ
    STAINTON, C
    DAVIES, JA
    TRANSPLANTATION PROCEEDINGS, 1986, 18 (06) : 1643 - 1643
  • [29] THE ROLE OF UROKINASE IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY
    STICKLAND, MH
    RAYNER, HC
    CREIGHTONKEMPSFORD, L
    GAFFNEY, PJ
    GRANT, PJ
    DIABETOLOGIA, 1992, 35 : A145 - A145
  • [30] Transcription factors in the pathogenesis of diabetic nephropathy
    Sanchez, Amber Paratore
    Sharma, Kumar
    EXPERT REVIEWS IN MOLECULAR MEDICINE, 2009, 11
12345