Epigenetics in the pathogenesis of diabetic nephropathy

被引：78

作者：

Li, Xue ^{[1
]}

Lu, Lihong ^{[1
]}

Hou, Wenting ^{[1
]}

Huang, Ting ^{[1
]}

Chen, Xiangyuan ^{[1
]}

Qi, Jie ^{[2
]}

Zhao, Yanjun ^{[3
]}

Zhu, Minmin ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll, Dept Anesthesiol,Dept Oncol, Shanghai 200032, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Anesthesiol, Sch Med, Shanghai 200080, Peoples R China

[3] Fudan Univ, Eye & ENT Hosp, Dept Anesthesiol, Shanghai 200031, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2022年 / 54卷 / 02期

基金：

美国国家科学基金会;

关键词：

diabetes; diabetic nephropathy; epigenetics; metabolic memory; LONG NONCODING RNA; GLYCATION END-PRODUCTS; HISTONE DEACETYLASE; GENE-EXPRESSION; HYPERGLYCEMIC MEMORY; METABOLIC-REGULATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; PODOCYTE INJURY; DNA METHYLATION;

D O I：

10.3724/abbs.2021016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an important impact on the development of DN through a variety of mechanisms, and promotes the generation and maintenance of metabolic memory, thus ultimately leading to a poor prognosis. In this review we discuss the methylation of DNA, modification of histone, and regulation of non-coding RNA involved in the progress of cell dysfunction, inflammation and fibrosis in the kidney, which ultimately lead to the deterioration of DN.

引用

页码：163 / 172

页数：10

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