Fast and Reliable Quantitative Peptidomics with labelpepmatch

被引：7

作者：

Verdonck, Rik ^{[1
]}

De Haes, Wouter ^{[1
]}

Cardoen, Dries ^{[1
]}

Menschaert, Gerben ^{[2
]}

Huhn, Thomas ^{[3
]}

Landuyt, Bart ^{[1
]}

Baggerman, Geert ^{[4
,5
]}

Boonen, Kurt ^{[1
]}

Wenseleers, Tom ^{[1
]}

Schoofs, Liliane ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Biol, Leuven, Belgium

[2] Univ Ghent, Res Grp Bioinformat & Computat Genom, B-9000 Ghent, Belgium

[3] Univ Konstanz, Dept Chem, Constance, Germany

[4] Univ Antwerp, CFP CeProMa, B-2020 Antwerp, Belgium

[5] Vlaamse Instelling Technol Onderzoek, Appl Bio & Mol Syst, Boeretang 200, B-2400 Mol, Belgium

来源：

JOURNAL OF PROTEOME RESEARCH | 2016年 / 15卷 / 03期

关键词：

isotope tag; label; neuropeptide; peptide; peptidomics; TMAB; PBAN; pyrokinin; hugin; locust; ION-TRANSPORT PEPTIDE; LOCUST SCHISTOCERCA-GREGARIA; MASS-SPECTROMETRY; ENDOGENOUS PEPTIDES; BEHAVIORAL GREGARIZATION; MOLECULAR MARKERS; FEEDING-BEHAVIOR; DIAPAUSE HORMONE; CORPUS CARDIACUM; DESERT LOCUSTS;

D O I：

10.1021/acs.jproteome.5b00845

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of stable isotope tags in quantitative peptidomics offers many advantages, but the laborious identification of matching sets of labeled peptide peaks is still a major bottleneck. Here we present labelpepmatch, an R package for fast and straightforward analysis of LC MS spectra of labeled peptides. This open-source tool offers fast and accurate identification of peak pairs alongside an appropriate framework for statistical inference on quantitative peptidomics data, based on techniques from other-omics disciplines. A relevant case study on the desert locust Schistocerca gregaria proves our pipeline to be a reliable tool for quick but thorough explorative analyses.

引用

页码：1080 / 1089

页数：10

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