Case Report: Nintedanib for Pembrolizumab-Related Pneumonitis in a Patient With Non-Small Cell Lung Cancer

被引：10
|
作者：
Xie, Xiao-Hong [1 ]
Deng, Hai-Yi [1 ]
Lin, Xin-Qing [1 ]
Wu, Jian-Hui [1 ]
Liu, Ming [1 ]
Xie, Zhan-Hong [1 ]
Qin, Yin-Yin [1 ]
Zhou, Cheng-Zhi [1 ]
机构：
[1] Guangzhou Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Resp Dis, Stale Key Lab Resp Dis,Guangzhou Inst Resp Hlth, Guangzhou, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词：
checkpoint inhibitor-related pneumonitis; nintedanib; steroid therapy; non-small cell lung cancer; pembrolizumab; IMMUNOTHERAPY;
D O I：
10.3389/fonc.2021.673877
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pembrolizumab, an immune checkpoint inhibitor (ICI) approved for advanced non-small cell lung cancer (NSCLC) treatment, has shown superior survival benefits. However, pembrolizumab may lead to severe immune-related adverse events (irAEs), such as checkpoint inhibitor-related pneumonitis (CIP). The routine treatment of CIP was based on systemic corticosteroids, but the therapies are limited for patients who are unsuitable for steroid therapy. Here, we present the first successful treatment of nintedanib for pembrolizumab-related pneumonitis in a patient with advanced NSCLC.
引用
收藏
页数：4
相关论文
共 50 条
  • [21] Nintedanib in an elderly non-small-cell lung cancer patient with severe steroid-refractory checkpoint inhibitor-related pneumonitis: A case report and literature review
    Pan, Lei
    Meng, Fanqi
    Wang, Wei
    Wang, Xu-hao
    Shen, Hui
    Bao, Pengchen
    Kang, Jian
    Kong, Delei
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [22] Pembrolizumab-Associated Stevens-Johnson Syndrome in a Patient With Metastatic Non-small Cell Lung Cancer: A Case Report
    Sandhu, Michael
    Binod, K. C.
    Bhandari, Jenish
    Gambhir, Harvir S.
    Farah, Ramsay
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (07)
  • [23] A case of cerebellar ataxia caused by Pembrolizumab for Non-small cell lung cancer
    Moto, T.
    Nagayama, H.
    Kimura, K.
    MOVEMENT DISORDERS, 2019, 34 : S115 - S116
  • [24] Acute myelomonocytic leukemia during pembrolizumab treatment for non-small cell lung cancer: A case report
    Hong-Beum Kim
    Sang-Gon Park
    Ran Hong
    Seong-Ho Kang
    Yong Sub Na
    World Journal of Clinical Cases, 2020, (13) : 2833 - 2840
  • [25] Acute myelomonocytic leukemia during pembrolizumab treatment for non-small cell lung cancer: A case report
    Kim, Hong-Beum
    Park, Sang-Gon
    Hong, Ran
    Kang, Seong-Ho
    Na, Yong Sub
    WORLD JOURNAL OF CLINICAL CASES, 2020, 8 (13) : 2833 - 2840
  • [26] Pembrolizumab for choroidal metastases from non-small cell lung cancer: a case report and literature review
    Li, Xinsheng
    Liang, Ya
    Wang, Jingfan
    Hu, Zizhong
    Yuan, Zhi-Lan
    Xie, Ping
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2021, 17 (08) : 2626 - 2629
  • [27] PEMBROLIZUMAB-RELATED FOATAL MYOCARDITIS - A CASE REPORT
    Vu, Linh Hue
    Courtney, Bennett
    RESPIROLOGY, 2019, 24 : 214 - 214
  • [28] Acquired Hemophilia in an Elderly Patient with Non-Small Cell Lung Cancer: a Case Report
    Antonio Dulcetti
    C. Bruscia
    D. M. Malena
    R. Benvenuto
    A. Martocchia
    A. Sentimentale
    L. Tafaro
    M. Rocchietti March
    P. Martelletti
    SN Comprehensive Clinical Medicine, 5 (1)
  • [29] Pembrolizumab-Related Sclerosing Cholangitis in a Patient With High Microsatellite Instability Gastric Cancer: A Case Report
    Honma, Shusaku
    Watanabe, Satoshi
    Nakajima, Sanae
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (08)
  • [30] Myositis induced by durvalumab in a patient with non-small cell lung cancer: A case report
    Kobayashi, Miyuki
    Saiki, Masafumi
    Omori, Chisa
    Ide, Shuichiro
    Masuda, Kazuki
    Sogami, Yusuke
    Hata, Takanori
    Ishihara, Hiroshi
    THORACIC CANCER, 2020, 11 (12) : 3614 - 3617
12345