Bioreducible polymers for therapeutic gene delivery

被引：58

作者：

Lee, Young Sook ^{[1
]}

Kim, Sung Wan ^{[1
,2
]}

机构：

[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Ctr Controlled Chem Delivery, Salt Lake City, UT 84112 USA

[2] Hanyang Univ, Coll Engn, Dept Bioengn, Seoul 133791, South Korea

来源：

JOURNAL OF CONTROLLED RELEASE | 2014年 / 190卷

关键词：

Bioreducible polymer; Gene; Cardiovascular disease; Diabetes; Oncolytic adenovirus; Targeting; BIO-REDUCIBLE POLYMER; ONCOLYTIC ADENOVIRUS; SIRNA DELIVERY; MYOCARDIAL-INFARCTION; PLASMID DNA; POLY(TRIETHYLENETETRAMINE/CYSTAMINE BISACRYLAMIDE); POLY(DISULFIDE AMINE); BIODEGRADABLE POLYMER; POLYPLEX MICELLES; PANCREATIC-ISLETS;

D O I：

10.1016/j.jconrel.2014.04.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Most currently available cationic polymers have significant acute toxicity concerns such as cellular toxicity, aggregation of erythrocytes, and entrapment in the lung capillary bed, largely due to their poor biocompatibility and non-degradability under physiological conditions. To develop more intelligent polymers, disulfide bonds are introduced in the design of biodegradable polymers. Herein, the sustained innovations of biomimetic nano-sized constructs with bioreducible poly(disulfide amine)s demonstrate a viable clinical tool for the treatment of cardiovascular disease, anemia, diabetes, and cancer. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：424 / 439

页数：16

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