Retinal Microvascular Changes in COVID-19 Bilateral Pneumonia Based on Optical Coherence Tomography Angiography

被引:16
|
作者
Kal, Magdalena [1 ,2 ]
Winiarczyk, Mateusz [3 ]
Ciesla, Elzbieta [4 ]
Platkowska-Adamska, Bernadetta [1 ,2 ]
Walczyk, Anna [2 ]
Biskup, Michal [2 ]
Pabjan, Pawel [4 ,5 ]
Gluszek, Stanislaw [1 ]
Odrobina, Dominik [2 ,4 ]
Mackiewicz, Jerzy [3 ]
Zarebska-Michaluk, Dorota [1 ,5 ]
机构
[1] Jan Kochanowski Univ, Coll Med, PL-25369 Kielce, Poland
[2] Voivodeship Hosp, Ophthalm Clin, PL-25736 Kielce, Poland
[3] Med Univ Lublin, Dept Vitreoretinal Surg, PL-20819 Lublin, Poland
[4] Jan Kochanowski Univ, Inst Med Sci, PL-25369 Kielce, Poland
[5] Prov Hosp, Dept Infect Dis, PL-25317 Kielce, Poland
关键词
COVID-19; SARS-CoV-2; microvasculature changes; OCTA; optical coherence tomography; angiography; retinal microvasculature; retina; FAZ; foveal avascular zone; RECEPTOR; ACE2;
D O I
10.3390/jcm11133621
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of this study was to evaluate retinal and choroidal microvascular alterations with optical coherence tomography angiography (OCTA) in COVID-19 patients hospitalized because of bilateral pneumonia caused by SARS-CoV-2. The vessel density (VD) and foveal avascular zone (FAZ) of 63 patients with SARS-CoV-2 pneumonia who had positive polymerase chain reaction (PCR) tests and who recovered after receiving treatment and 45 healthy age- and gender-matched controls were evaluated and compared using OCTA in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). The VD was also estimated in both groups in the choriocapillaris (CC). In COVID-19 patients, there was a statistically significant difference between the patients and a control group in both superficial (FAZs) and deep (FAZd) avascular zone (p = 0.000). The VD was significantly lower in the foveal area in choriocapillaris (p = 0.046). There were no statistically significant changes in the VD in the superior, inferior, nasal, and temporal quadrants in superficial and deep plexus, or in the choriocapillaris. The VD was not significantly lower in the foveal area in superficial or deep plexus. COVID-19 may affect the retinal vasculature, causing ischemia, enlargement of the FAZ, and lowering of the VD in the choriocapillaris area. Routine ophthalmic examination after SARS-CoV-2 infection should be considered in the course of post-infectious rehabilitation.
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页数:12
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