Chemistry Nobel Honors CRISPR-Cas9

被引：0
|
作者：
You Li-Lan [1 ,2 ]
Sun Wei [1 ]
Yang Xiao-Qi [1 ,2 ]
Wang Yan-Li [1 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2020年 / 47卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Nobel Prize in Chemistry; CRISPR-Cas9; gene-editing; RNA; REPEATS; GENE; IDENTIFICATION; ENDONUCLEASE; SEQUENCES; CLEAVAGE; IMMUNITY;
D O I：
10.16476/j.pibb.2020.0395
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna "for the development of CRISPR genome editing tool". They have discovered the sharpest tools for gene editing: the CRISPR/Cas9 genetic scissors, which have revolutionary impact on life sciences. The CRISPR system is an adaptive immune system in prokaryotes. Cas9, an effector protein of type. CRISPR-Cas system, functions as a dual-RNA-guided DNA endonuclease, which is able to cleave any dsDNA generating dsDNA break. The CRISPR-Cas9 has been widely used in gene editing, due to its simplicity, high efficiency and low price. This paper introduces the research findings of 2020 Chemistry Nobel Prize winners, summarizes the discovery process of CRISPR system and the activity and application of CRISPR-Cas9.
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收藏
页码：1119 / 1126
页数：8
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