Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

被引：35

作者：

Horton, JR ^{[1
]}

Bostock, JM ^{[1
]}

Chopra, I ^{[1
]}

Hesse, L ^{[1
]}

Phillips, SEV ^{[1
]}

Adams, DJ ^{[1
]}

Johnson, AP ^{[1
]}

Fishwick, CWG ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(03)00176-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1557 / 1560

页数：4

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