Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

被引：35
|
作者：
Horton, JR [1 ]
Bostock, JM [1 ]
Chopra, I [1 ]
Hesse, L [1 ]
Phillips, SEV [1 ]
Adams, DJ [1 ]
Johnson, AP [1 ]
Fishwick, CWG [1 ]
机构：
[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期
关键词：
D O I：
10.1016/S0960-894X(03)00176-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1557 / 1560
页数：4
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