Influence of the NR3A subunit on NMDA receptor functions

被引：126
|
作者：
Henson, Maile A. [1 ,2 ]
Roberts, Adam C. [1 ,2 ]
Perez-Otano, Isabel [3 ,4 ]
Philpot, Benjamin D. [1 ,2 ]
机构：
[1] Univ N Carolina, Curriculum Neurobiol, Neurodev Disorders Res Ctr, Ctr Neurosci, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA
[3] CIMA, Dept Neurociencias, Cellular Neurobiol Lab, Pamplona 31008, Spain
[4] Univ Navarra, Pamplona 31008, Spain
来源：
PROGRESS IN NEUROBIOLOGY | 2010年 / 91卷 / 01期
基金：
美国国家科学基金会;
关键词：
NR3A; NMDA receptor; Synaptic plasticity; Neurodevelopmental disorders; Dendritic spine; NMDA subunit; LTP; Synapse elimination; Synapse maturation; D-ASPARTATE-RECEPTORS; TREATMENT-RESISTANT SCHIZOPHRENIA; TERM SYNAPTIC PLASTICITY; DENDRITIC SPINE DENSITY; PROTEIN PHOSPHATASE 2A; LIGAND-BINDING DOMAIN; ER RETENTION SIGNAL; GLUTAMATE-RECEPTOR; RAT-BRAIN; SPLICE VARIANTS;
D O I：
10.1016/j.pneurobio.2010.01.004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Various combinations of subunits assemble to form the NMDA-type glutamate receptor (NMDAR), generating diversity in its functions. Here we review roles of the unique NMDAR subunit, NR3A, which acts in a dominant-negative manner to suppress receptor activity. NR3A-containing NMDARs display striking regional and temporal expression specificity, and, unlike most other NMDAR subtypes, they have a low conductance, are only modestly permeable to Ca2+, and pass current at hyperpolarized potentials in the presence of magnesium. While glutamate activates triheteromeric NMDARs composed of NR1/NR2/NR3A subunits, glycine is sufficient to activate diheteromeric NR1/NR3A-containing receptors. NR3A dysfunction may contribute to neurological disorders involving NMDARs, and the subunit offers an attractive therapeutic target given its distinct pharmacological and structural properties. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：23 / 37
页数：15
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