Synchronous hepatocellular carcinoma with renal cell carcinoma: a case report and review of literature

The discovery of synchronous double malignancies in the same patient is not uncommon. Whereas coexistence of hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) is extremely rare, and the number of reported cases is very limited in the English-language literature to date. We present a case of a 53-year-old man who was found to have HCC and RCC during an incidental medical examination. The patient underwent left hemihepatectomy and right radical nephrectomy, and histological and immunohistochemical examination confirmed that the tumor originating from the left lateral hepatic lobe was HCC, and the tumor arising from the lower portion of the right kidney was clear cell RCC. A follow-up period of 18 months was uneventful. The pathogenesis and previous related reports of these lesions are discussed.