DROPLET FLOW FOCUSING FOR MOLECULAR BINDING DETECTION

被引：0
|
作者：
Kim, Sunggu [1 ]
Lee, Junghoon [1 ]
机构：
[1] Seoul Natl Univ, Seoul, South Korea
来源：
2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015) | 2015年
关键词：
SIZE;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We report the detection of interfacial molecular binding via droplet generation in a flow focusing device. DNA hybridization at the phospholipid causes interfacial tension shift at the oil-water boundary which changes the mode of droplet production in the device. Droplet size decreased similar to 30% due to a complementary binding compared with non-complementary and control cases. Our report includes a molecular protocol to functionalize the interface with single-strand (ss) DNA as receptor and flow condition tuning for an unambiguous distinction of complementary binding.
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页码：230 / 233
页数：4
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