Clinical applications of pharmacogenetics

被引：10

作者：

Quinones, Luis ^{[1
]}

Roco, Angela ^{[1
,2
,6
]}

Cayun, Juan P. ^{[1
]}

Escalante, Paula ^{[1
]}

Miranda, Carla ^{[1
]}

Varela, Nelson ^{[1
]}

Meneses, Francisca ^{[3
]}

Gallegos, Bastian ^{[3
]}

Zaruma-Torres, Fausto ^{[4
,5
]}

Lares-Asseff, Ismael ^{[4
]}

机构：

[1] Univ Chile, Fac Med, Dept Oncol Basico Clin, Lab Carcinogenesis Quim & Farmacogenet, Santiago, Chile

[2] MINSAL, Serv Salud Metropolitano Occidente, Departamento Coordinac Red Asistencial, Santiago, Chile

[3] Univ Santo Tomas, Escuela Tecnol Med, Santiago, Chile

[4] Inst Politecn Nacl, Durango, Mexico

[5] Univ Cuenca, Escuela Bioquim & Farm, Cuenca, Ecuador

[6] Univ Andres Bello, Fac Ciencias, Escuela Bioquim, Santiago, Chile

来源：

REVISTA MEDICA DE CHILE | 2017年 / 145卷 / 04期

关键词：

Pharmacogenetics; Pharmacokinetics; Pharmacogenomic variants; Polymorphisms; Genetic; DRUG-METABOLIZING-ENZYMES; IMPLEMENTATION CONSORTIUM GUIDELINES; INDIVIDUALIZED MEDICINE; PERSONALIZED MEDICINE; BREAST-CANCER; POLYMORPHISMS; GENOTYPE; TOXICITY; THERAPY; TRANSPORTERS;

D O I：

10.4067/S0034-98872017000400009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pharmacogenetics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.

引用

页码：483 / 500

页数：18

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