Bis(thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

被引：68
|
作者：
Fodero-Tavoletti, Michelle T. [2 ,3 ,4 ]
Villemagne, Victor L. [1 ,2 ,4 ]
Paterson, Brett M. [3 ,5 ]
White, Anthony R. [2 ,4 ,6 ]
Li, Qiao-Xin [2 ,4 ]
Camakaris, James [7 ]
O'Keefe, Graeme J. [1 ]
Cappai, Roberto [2 ,3 ]
Barnham, Kevin J. [2 ,3 ,4 ]
Donnelly, Paul S. [3 ,5 ]
机构：
[1] Austin Hlth, Ctr PET, Dept Nucl Med, Heidelberg, Vic 3010, Australia
[2] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia
[3] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia
[4] Mental Hlth Res Inst, Melbourne, Vic, Australia
[5] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
[6] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia
[7] Univ Melbourne, Dept Genet, Melbourne, Vic 3010, Australia
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 20卷 / 01期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
Alzheimer's disease; copper homeostasis; copper radiopharmaceuticals; diagnostic imaging; positron emission tomography (PET); AMYLOID-BETA-PEPTIDE; A-BETA; IN-VITRO; COPPER; BINDING; MECHANISMS; OLIGOMERS; BRAIN; ZINC; MICE;
D O I：
10.3233/JAD-2010-1359
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.
引用
收藏
页码：49 / 55
页数：7
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