Denosumab-Associated Severe Hypocalcemia in a Patient With Chronic Kidney Disease

被引：8

作者：

Salim, Sohail Abdul ^{[1
]}

Nair, Lakshmi Ramachandran ^{[2
]}

Thomas, Litty ^{[1
]}

Garla, Vishnu ^{[2
]}

Palabindala, Venkataraman ^{[3
]}

Agarwal, Mohit ^{[1
]}

Fulop, Tibor ^{[4
,5
]}

机构：

[1] Univ Mississippi, Med Ctr, Dept Internal Med, Div Nephrol, Jackson, MS 39216 USA

[2] Univ Mississippi, Med Ctr, Div Endocrinol, Jackson, MS 39216 USA

[3] Univ Mississippi, Med Ctr, Div Hosp Med, Jackson, MS 39216 USA

[4] Univ Debrecen, Fac Med, Dept Med, Div Nephrol, Debrecen, Hungary

[5] Fresenius Med Care, FMC Extracorporeal Life Support Ctr, Esztergom, Hungary

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2018年 / 355卷 / 05期

关键词：

Alkaline phosphatase; End-stage renal disease; Hypercalcemia of malignancy; Parathyroid hormone; RANKL inhibitor; MULTIPLE-MYELOMA; BONE METASTASES; OSTEOPROTEGERIN; CANCER; ACID;

D O I：

10.1016/j.amjms.2017.09.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Denosumab is a monoclonal antibody directed against the receptor activator of nuclear factor kappa B ligand (RANKL). Denosumab has been shown to reduce the risk of skeletal-related events, including spinal cord compression, pathologic fracture and hypercalcemia of malignancy in patients with bone metastases. Hypocalcemia is a known side effect of denosumab, occurring in an estimated 8-14% of the patients. Here, we present an asymptomatic patient with stage-5 chronic kidney disease and severe hypocalcemia who had received denosumab 1 month earlier.

引用

页码：506 / 509

页数：4

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