Sigma-1 Receptor Antagonist Haloperidol Attenuates Store-Dependent Ca2+ Entry in Macrophages

被引：3

作者：

Krutetskaya, Z. I. ^{[1
]}

Milenina, L. S. ^{[1
]}

Naumova, A. A. ^{[1
]}

Butov, S. N. ^{[1
]}

Antonov, V. G. ^{[1
]}

Nozdrachev, A. D. ^{[1
]}

机构：

[1] St Petersburg State Univ, St Petersburg 199034, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2018年 / 480卷 / 01期

关键词：

CALCIUM-ENTRY; SECRETION; CHANNELS;

D O I：

10.1134/S1607672918030109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with sigma-1 receptor antagonist haloperidol leads to a significant inhibition of the store-dependent Ca2+ entry induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of the sigma-1 receptor in the regulation of store-dependent Ca2+ entry in macrophages.

引用

页码：162 / 165

页数：4

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