New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells

被引：0
|
作者：
Mimaki, Y [1 ]
Kuroda, M [1 ]
Kameyama, A [1 ]
Yokosuka, A [1 ]
Sashida, Y [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 19203, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 02期
关键词：
Ruscus aculeatus; Liliaceae; spirostanol saponin; furostanol saponin; cytostatic activity; HL-60; cell;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Phytochemical examination of the underground parts of Riscus aculeatus has led to the isolation of a total of twelve steroidal saponins, including seven new ones, The structures of the new saponins were determined by spectroscopic analysis and chemical evidence. The furostanol saponin, having a diglycoside moiety modified with a (2S,3S)-2-hydroxy-3-methylpentanoic acid group and an acetic acid group, and its corresponding spirostanol saponin exhibited cytostatic activity on leukemia HL-60 cells.
引用
收藏
页码：298 / 303
页数：6
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