Characterization of a novel ADPase in Bothrops jararaca snake venom involved in nucleotide hydrolysis

被引：4
|
作者：
Teixeira-Ferreira, Andre [1 ]
Walter Alves, Elias [1 ]
机构：
[1] Univ Estad Norte Fluminense, Lab Quim & Funcao Prot & Peptideos, BR-28013300 Campos Dos Goytacazes, RJ, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2007年 / 14卷 / 04期
关键词：
Bothrops jararaca; ATP-pyrophosphatase; ATPasc; ADPase; phosphodiesterase; 5 '-nucleotidase;
D O I：
10.2174/092986607780363998
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme(s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.
引用
收藏
页码：395 / 402
页数：8
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