Nanog promotes stem-like traits of glioblastoma cells

被引：12
|
作者：
Yuan, Ye [1 ,2 ,3 ]
Zhang, Mengsi [1 ,2 ,3 ]
Yan, Guangning [4 ]
Ma, Qinghua [1 ,2 ,3 ]
Yan, Zexuan [1 ,2 ,3 ]
Wang, Lihong [1 ,2 ,3 ]
Yang, Kaidi [1 ,2 ,3 ]
Guo, Deyu [1 ,2 ,3 ]
机构：
[1] Third Mil Med Univ, Southwest Hosp, Inst Pathol, Army Med Univ, Chongqing, Peoples R China
[2] Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Army Med Univ, Chongqing, Peoples R China
[3] Mil Educ China, Key Lab Tumor Immunopathol, Chongqing, Peoples R China
[4] Gen Hosp Southern Theatre Command, Dept Pathol, Peoples Liberat Army, Guangzhou, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2021年 / 26卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Glioblastoma; Nanog; Stemness; migration; invasion; Hedgehog signaling pathway; INHIBITOR; RESISTANCE; APOPTOSIS; GANT-61; SANT-1;
D O I：
10.2741/4907
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in the pluripotency of embryonic stem cells (ESCs) and the induction of malignancy in cancer stem-like cells (CSCs). Bioinformatic analysis revealed that NANOG may be associated with the development of stem-like traits in GBM. Forced expression of NANOG markedly increased the expression of cancer stem cell markers and promoted the sphere formation and migration of GBM cells. Nanog enhanced the expression of SHH which is required for the maintenance of the positive feedback loop of Hedgehog signaling pathway. Treatment of GBM cells with SANT-1 and GANT61 significantly reduced the tumor progression. These data support a view that reduction of Nanog might have therapeutic benefits in GBM.
引用
收藏
页码：552 / 565
页数：14
相关论文
共 50 条
  • [21] Glioblastoma stem-like cells give rise to tumour endothelium
    Wang, Rong
    Chadalavada, Kalyani
    Wilshire, Jennifer
    Kowalik, Urszula
    Hovinga, Koos E.
    Geber, Adam
    Fligelman, Boris
    Leversha, Margaret
    Brennan, Cameron
    Tabar, Viviane
    NATURE, 2010, 468 (7325) : 829 - U128
  • [22] Glioblastoma stem-like cells give rise to tumour endothelium
    Rong Wang
    Kalyani Chadalavada
    Jennifer Wilshire
    Urszula Kowalik
    Koos E. Hovinga
    Adam Geber
    Boris Fligelman
    Margaret Leversha
    Cameron Brennan
    Viviane Tabar
    Nature, 2010, 468 : 829 - 833
  • [23] A major role for microRNAs in glioblastoma cancer stem-like cells
    Hong Wei Yang
    Hongyan Xing
    Mark D. Johnson
    Archives of Pharmacal Research, 2015, 38 : 423 - 434
  • [24] TRIM8 modulates stem-like cells in glioblastoma
    Zhang, Changming
    Subhas, Mukherjee
    Carol, Tucker-Burden
    Chau, Monica
    Kong, Jun
    Brat, Daniel
    CANCER RESEARCH, 2016, 76
  • [25] Adenosine and its role in stemness of glioblastoma stem-like cells
    Uribe Brange, D.
    Wagner, G.
    Niechi, I.
    Rocha, J. D.
    San Martin, R.
    Quezada, C.
    FEBS OPEN BIO, 2018, 8 : 341 - 342
  • [26] Correlation between glioblastoma stem-like cells and tumor vascularization
    He, Hu
    Niu, Chao Shi
    Li, Ming Wu
    ONCOLOGY REPORTS, 2012, 27 (01) : 45 - 50
  • [27] A major role for microRNAs in glioblastoma cancer stem-like cells
    Yang, Hong Wei
    Xing, Hongyan
    Johnson, Mark D.
    ARCHIVES OF PHARMACAL RESEARCH, 2015, 38 (03) : 423 - 434
  • [28] Astrocytes Enhance the Invasion Potential of Glioblastoma Stem-Like Cells
    Rath, Barbara H.
    Fair, Joshlean M.
    Jamal, Muhammad
    Camphausen, Kevin
    Tofilon, Philip J.
    PLOS ONE, 2013, 8 (01):
  • [29] Boswellic acid activity against glioblastoma stem-like cells
    Schneider, Hannah
    Weller, Michael
    ONCOLOGY LETTERS, 2016, 11 (06) : 4187 - 4192
  • [30] HETEROGENEITY AND DISTRIBUTION OF TUMOR STEM-LIKE CELLS IN HUMAN GLIOBLASTOMA
    Piccirillo, S.
    Watts, C.
    NEURO-ONCOLOGY, 2010, 12 : 7 - 7
12345