Nanog promotes stem-like traits of glioblastoma cells

被引：12
|
作者：
Yuan, Ye [1 ,2 ,3 ]
Zhang, Mengsi [1 ,2 ,3 ]
Yan, Guangning [4 ]
Ma, Qinghua [1 ,2 ,3 ]
Yan, Zexuan [1 ,2 ,3 ]
Wang, Lihong [1 ,2 ,3 ]
Yang, Kaidi [1 ,2 ,3 ]
Guo, Deyu [1 ,2 ,3 ]
机构：
[1] Third Mil Med Univ, Southwest Hosp, Inst Pathol, Army Med Univ, Chongqing, Peoples R China
[2] Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Army Med Univ, Chongqing, Peoples R China
[3] Mil Educ China, Key Lab Tumor Immunopathol, Chongqing, Peoples R China
[4] Gen Hosp Southern Theatre Command, Dept Pathol, Peoples Liberat Army, Guangzhou, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2021年 / 26卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Glioblastoma; Nanog; Stemness; migration; invasion; Hedgehog signaling pathway; INHIBITOR; RESISTANCE; APOPTOSIS; GANT-61; SANT-1;
D O I：
10.2741/4907
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in the pluripotency of embryonic stem cells (ESCs) and the induction of malignancy in cancer stem-like cells (CSCs). Bioinformatic analysis revealed that NANOG may be associated with the development of stem-like traits in GBM. Forced expression of NANOG markedly increased the expression of cancer stem cell markers and promoted the sphere formation and migration of GBM cells. Nanog enhanced the expression of SHH which is required for the maintenance of the positive feedback loop of Hedgehog signaling pathway. Treatment of GBM cells with SANT-1 and GANT61 significantly reduced the tumor progression. These data support a view that reduction of Nanog might have therapeutic benefits in GBM.
引用
收藏
页码：552 / 565
页数：14
相关论文
共 50 条
  • [1] Nanog signaling in cancer promotes stem-like phenotype and immune evasion
    Noh, Kyung Hee
    Kim, Bo Wook
    Song, Kwon-Ho
    Cho, Hanbyoul
    Lee, Young-Ho
    Kim, Jin Hee
    Chung, Joon-Yong
    Kim, Jae-Hoon
    Hewitt, Stephen M.
    Seong, Seung-Yong
    Mao, Chih-Ping
    Wu, T. -C.
    Kim, Tae Woo
    JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (11): : 4077 - 4093
  • [2] miR-367 promotes proliferation and stem-like traits in medulloblastoma cells
    Kaid, Carolini
    Silva, Patricia B. G.
    Cortez, Beatriz A.
    Rodini, Carolina O.
    Semedo-Kuriki, Patricia
    Okamoto, Oswaldo K.
    CANCER SCIENCE, 2015, 106 (09): : 1188 - 1195
  • [3] EGFR Amplification and Glioblastoma Stem-Like Cells
    Liffers, Katrin
    Lamszus, Katrin
    Schulte, Alexander
    STEM CELLS INTERNATIONAL, 2015, 2015
  • [4] Molecular analyses of glioblastoma stem-like cells and glioblastoma tissue
    Wallenborn, Marco
    Xu, Li-Xin
    Kirsten, Holger
    Rohani, Leili
    Rudolf, Daniela
    Ahnert, Peter
    Schmidt, Christian
    Schulz, Ronny M.
    Richter, Mandy
    Krupp, Wolfgang
    Mueller, Wolf
    Johnson, Adiv A.
    Meixensberger, Juergen
    Holland, Heidrun
    PLOS ONE, 2020, 15 (07):
  • [5] MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
    Todorova, Pavlina Krasimirova
    Mukherjee, Bipasha
    Burma, Sandeep
    ANNALS OF TRANSLATIONAL MEDICINE, 2017, 5 (03)
  • [6] Identification of Dysregulated microRNAs in Glioblastoma Stem-like Cells
    Evers, Lara
    Schaefer, Agnes
    Pini, Raffaella
    Zhao, Kai
    Stei, Susanne
    Nimsky, Christopher
    Bartsch, Joerg W.
    BRAIN SCIENCES, 2023, 13 (02)
  • [7] Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy
    Yi, Yang
    Hsieh, I-Yun
    Huang, Xiaojia
    Li, Jie
    Zhao, Wei
    FRONTIERS IN PHARMACOLOGY, 2016, 7
  • [8] Chemoresistance of stem-like cells isolated from glioblastoma
    Liu, Gentao
    Yuan, Xiangpeng
    Zeng, Zhaohui
    Ng, Hiushan
    Tunici, Patrizia
    Irvin, Dwain
    Black, Keith L.
    Yu, John S.
    CANCER RESEARCH, 2006, 66 (08)
  • [9] Translational Impact of Glioblastoma Cancer Stem-Like Cells
    Larocca, L. M.
    Vitiani, L. Ricci
    D'Alessandris, Q. G.
    Cenci, T.
    Martini, M.
    De Maria, R.
    Pallini, R.
    MODERN PATHOLOGY, 2014, 27 : 438A - 438A
  • [10] Stem-like cells and CRMP5 in Glioblastoma
    Thomasset, Nicole
    Bertrand, Caroline
    Meilac, Thomas
    Malleval, Celine
    Chounlamountri, Naura
    Rogend, Veronique
    Honnorat, Jerome
    BULLETIN DU CANCER, 2010, 97 : S89 - S90
12345