Spinal metastasis: narrative reviews of the current evidence and treatment modalities

被引:18
|
作者
Jaipanya, Pilan [1 ,2 ]
Chanplakorn, Pongsthorn [2 ]
机构
[1] Mahidol Univ, Chakri Naruebodindra Med Inst, Ramathibodi Hosp, Fac Med, Samut Prakan, Thailand
[2] Mahidol Univ, Ramathibodi Hosp, Dept Orthopaed, Fac Med, 270,Rama VI Rd, Bangkok 10400, Thailand
关键词
Spinal metastasis; spinal metastasis surgery; spinal cord compression; HIGH-DOSE DEXAMETHASONE; INSTABILITY NEOPLASTIC SCORE; LONG-COURSE RADIOTHERAPY; SKELETAL-RELATED EVENTS; CELL LUNG-CANCER; CORD COMPRESSION; PROGNOSTIC-FACTORS; ZOLEDRONIC ACID; BONE METASTASES; PERCUTANEOUS VERTEBROPLASTY;
D O I
10.1177/03000605221091665
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The treatment for spinal metastasis has evolved significantly during the past decade. An advancement in systemic therapy has led to a prolonged overall survival in cancer patients, thus increasing the incidence of spinal metastasis. In addition, with the improved treatment armamentarium, the prediction of patient survival using traditional prognostic models may have limitations and these require the incorporation of some novel parameters to improve their prognostic accuracy. The development of minimally-invasive spinal procedures and minimal access surgical techniques have facilitated a quicker patient recovery and return to systemic treatment. These modern interventions help to alleviate pain and improve quality of life, even in candidates with a relatively short life expectancy. Radiotherapy may be considered in non-surgical candidates or as adjuvant therapy for improving local tumour control. Stereotactic radiosurgery has facilitated this even in radioresistant tumours and may even replace surgery in radiosensitive malignancies. This narrative review summarizes the current evidence leading to the paradigm shifts in the modern treatment of spinal metastasis.
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页数:17
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