Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

被引：100

作者：

Vrieling, Alina ^{[2
]}

Bueno-de-Mesquita, H. Bas ^{[1
]}

Boshuizen, Hendriek C.

Michaud, Dominique S. ^{[3
]}

Severinsen, Marianne T. ^{[4
]}

Overvad, Kim ^{[4
]}

Olsen, Anja ^{[5
]}

Tjonneland, Anne ^{[5
]}

Clavel-Chapelon, Francoise ^{[6
,7
]}

Boutron-Ruault, Marie-Christine ^{[6
,7
]}

Kaaks, Rudolf ^{[8
]}

Rohrmann, Sabine ^{[8
]}

Boeing, Heiner ^{[9
]}

Noethlings, Ute ^{[9
]}

Trichopoulou, Antonia ^{[10
,11
]}

Moutsiou, Eftihia ^{[10
]}

Dilis, Vardis ^{[10
]}

Palli, Domenico ^{[12
]}

Krogh, Vittorio ^{[13
]}

Panico, Salvatore ^{[14
]}

Tumino, Rosario ^{[15
]}

Vineis, Paolo ^{[3
,16
]}

van Gils, Carla H. ^{[2
]}

Peeters, Petra H. M. ^{[2
]}

Lund, Eiliv ^{[17
]}

Gram, Inger T. ^{[17
]}

Rodriguez, Laudina ^{[18
]}

Agudo, Antonio ^{[19
]}

Larranaga, Nerea

Sanchez, Maria-Jose ^{[20
]}

Navarro, Carmen ^{[21
]}

Barricarte, Aurelio ^{[22
]}

Manjer, Jonas ^{[23
]}

Lindkvist, Bjorn ^{[24
]}

Sund, Malin ^{[25
,26
]}

Ye, Weimin ^{[27
,28
]}

Bingham, Sheila ^{[29
]}

Khaw, Kay-Tee ^{[30
]}

Roddam, Andrew ^{[31
]}

Key, Tim ^{[31
]}

Boffetta, Paolo ^{[32
]}

Duell, Eric J. ^{[32
]}

Jenab, Mazda ^{[32
]}

Gallo, Valentina ^{[3
]}

Riboli, Elio ^{[3
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr & Hlth, NL-3720 BA Bilthoven, Netherlands

[2] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[3] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] INSERM, ERI 20, EA 4045, F-75654 Paris 13, France

[7] Inst Gustave Roussy, Villejuif, France

[8] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[9] German Inst Human Nutr, Potsdam, Germany

[10] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[11] Helenic Hlth Fdn, Athens, Greece

[12] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[13] Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, Italy

[14] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy

[15] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[16] ISI Fdn, Turin, Italy

[17] Univ Tromso, Inst Community Med, Tromso, Norway

[18] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[19] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[20] Andalusian Sch Publ Hlth, Granada, Spain

[21] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[22] Publ Hlth Inst Navarra, Pamplona, Spain

[23] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[24] Sahlgrens Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Gothenburg, Sweden

[25] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[26] Umea Univ, Dept Clin Med, Umea, Sweden

[27] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[28] Umea Univ, Med Biobank, Umea, Sweden

[29] Univ Cambridge, MRC Ctr Nutr & Canc Prevent & Survival, Cambridge, England

[30] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[31] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[32] Int Agcy Res Canc, F-69372 Lyon, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2010年 / 126卷 / 10期

关键词：

pancreatic cancer; cigarette; smoking; environmental tobacco smoke; cohort study; DIABETES-MELLITUS; PASSIVE SMOKING; LIFE-STYLE; METAANALYSIS; ADENOCARCINOMA; COHORT; COFFEE;

D O I：

10.1002/ijc.24907

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% Cl = 1.36 2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% Cl = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% Cl = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% Cl = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.

引用

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页码：2394 / 2403

页数：10

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