More writing: mTORC1 promotes m6A mRNA methylation

被引:2
|
作者
Shetty, Sunil [1 ]
Hall, Michael N. [1 ]
机构
[1] Univ Basel, Biozentrum, Basel, Switzerland
关键词
CELL-GROWTH;
D O I
10.1016/j.molcel.2021.04.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cho et al. (2021) and Villa et al. (2021) demonstrate that mTORC1 stimulates m(6)A mRNA methylation via WTAP expression and SAM synthesis. Increased mRNA methylation in turn promotes cell growth by enhancing mRNA degradation or translation.
引用
收藏
页码:2057 / 2058
页数:2
相关论文
共 50 条
  • [41] Dissecting the roles of increased mRNA m6A methylation in autotetraploidization in Stevia rebaudiana
    Liu, Juan
    Tan, Mingpu
    Zhang, Yingying
    Zhao, Jie
    Liu, Huijie
    Liu, Peng
    Meng, Wenna
    Ding, Anping
    Xiang, Zengxu
    Chen, Mingjia
    PLANT GROWTH REGULATION, 2024, 104 (02) : 771 - 787
  • [42] From form to function: m6A methylation links mRNA structure to metabolism
    Cruz, Braulio Martinez De La
    Darsinou, Marousa
    Riccio, Antonella
    ADVANCES IN BIOLOGICAL REGULATION, 2023, 87
  • [43] Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer
    Wang, Xiuli
    Li, Zenghui
    Kong, Beihua
    Song, Chen
    Cong, Jianglin
    Hou, Jianqing
    Wang, Shaoguang
    ONCOTARGET, 2017, 8 (58) : 98918 - 98930
  • [44] m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells
    Wang, Yanqiu
    Sun, Jiajun
    Lin, Zhen
    Zhang, Weizhen
    Wang, Shu
    Wang, Weiqing
    Wang, Qidi
    Ning, Guang
    DIABETES, 2020, 69 (08) : 1708 - 1722
  • [45] m6A mRNA methylation in human brain is disrupted in Lewy body disorders
    de la Cruz, Braulio Martinez
    Gell, Chris
    Markus, Robert
    Macdonald, Ian
    Fray, Rupert
    Knight, Helen Miranda
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2023, 49 (01)
  • [46] Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
    Praveen Bawankar
    Tina Lence
    Chiara Paolantoni
    Irmgard U. Haussmann
    Migle Kazlauskiene
    Dominik Jacob
    Jan B. Heidelberger
    Florian M. Richter
    Mohanakarthik P. Nallasivan
    Violeta Morin
    Nastasja Kreim
    Petra Beli
    Mark Helm
    Martin Jinek
    Matthias Soller
    Jean-Yves Roignant
    Nature Communications, 12
  • [47] m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
    Geula, Shay
    Moshitch-Moshkovitz, Sharon
    Dominissini, Dan
    Mansour, Abed AlFatah
    Kol, Nitzan
    Salmon-Divon, Mali
    Hershkovitz, Vera
    Peer, Eyal
    Mor, Nofar
    Manor, Yair S.
    Ben-Haim, Moshe Shay
    Eyal, Eran
    Yunger, Sharon
    Pinto, Yishay
    Jaitin, Diego Adhemar
    Viukov, Sergey
    Rais, Yoach
    Krupalnik, Vladislav
    Chomsky, Elad
    Zerbib, Mirie
    Maza, Itay
    Rechavi, Yoav
    Massarwa, Rada
    Hanna, Suhair
    Amit, Ido
    Levanon, Erez Y.
    Amariglio, Ninette
    Stern-Ginossar, Noam
    Novershtern, Noa
    Rechavi, Gideon
    Hanna, Jacob H.
    SCIENCE, 2015, 347 (6225) : 1002 - 1006
  • [48] Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
    Bawankar, Praveen
    Lence, Tina
    Paolantoni, Chiara
    Haussmann, Irmgard U.
    Kazlauskiene, Migle
    Jacob, Dominik
    Heidelberger, Jan B.
    Richter, Florian M.
    Nallasivan, Mohanakarthik P.
    Morin, Violeta
    Kreim, Nastasja
    Beli, Petra
    Helm, Mark
    Jinek, Martin
    Soller, Matthias
    Roignant, Jean-Yves
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [49] THE CROSSTALK OF MTORC1 AND DNA METHYLATION IN HEPATOCELLULAR CARCINOMA
    Zeng, Judeng
    Chen, Meng-ke
    Zhang, Ning
    Xu, Li-xia
    Yang, Yang
    Xu, Xiao-yi
    Wang, Hui-yun
    Zheng, Steven Xiao-feng
    GUT, 2018, 67 : A24 - A24
  • [50] mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA
    Yang, Zhengming
    Yu, Wei
    Xu, Ankai
    Liu, Bing
    Jin, Libin
    Tao, Huimin
    Wang, Dimin
    CELL DEATH DISCOVERY, 2024, 10 (01)