Objective: The study aimed at examining predictors of hostility among university students in Jordan. Methods: Two-step multiple hierarchical regression analysis was used to examine the relationship between hostility, perceived stress, perceived social support, depression, moral commitment, life satisfaction and optimism utilizing data collected from 428 university students were recruited from six different universities in Jordan. Results: Life satisfaction, depression and perceived stress were significant predictors of hostility among university students (p < 0.05). Life satisfaction was inversely related, whereas depression and perceived stress were positively related to hostility. Male and female university students were not different in their hostility scores. Conclusion: Assessment of psychosocial well being is an important component to manage hostility among university students. The importance of psychosocial well being is highlighted and implications for mental health nurses and professionals are presented.