Synthesis and Prediction of Antitumor Activity of New Fused Pyrano[3,4-c]pyridines and Pyrano [4′,3′:4,5]pyrido[2,3-d]pyrimidines

被引：1

作者：

Dashyan, Sh Sh ^{[1
]}

Paronikyan, E. G. ^{[1
]}

Ayvazyan, A. S. ^{[1
]}

Mamyan, S. S. ^{[1
]}

Hunanyan, L. S. ^{[2
]}

机构：

[1] Natl Acad Sci Republ Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

[2] Russian Armenian Univ, Inst Biomed & Pharm, Yerevan 0051, Armenia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 03期

关键词：

one-pot method; thioxo(oxo)pyrano[3,4-c]pyridine; pyrano[4 ',3 ':4,5]pyrido[2,3-d]pyrimidine; antitumor activity; molecular docking;

D O I：

10.1134/S1070363222030069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot methods were developed for the preparation of 6-amino-3-isopropyl-7-aryl substituted-8-thioxo(oxo)pyrano [3,4-c]pyridines derivatives. The latter served as starting materials for the synthesis of a new py rano[4',3':4,5]pyrido[2,3-d]pyrimidine heterosystems. The proposed mechanisms of one-pot reactions were presented. Antitumor activity of new synthesized compounds was predicted by in silico methods.

引用

页码：383 / 392

页数：10

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