Enhancement of anti-tumor immunity by photodynamic therapy

被引：137

作者：

Gollnick, Sandra O. ^{[1
,2
]}

Brackett, Craig M. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

[2] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

来源：

IMMUNOLOGIC RESEARCH | 2010年 / 46卷 / 1-3期

关键词：

PDT; Neutrophil; Vaccine; T cell; COLONY-STIMULATING FACTOR; HEAT-SHOCK PROTEINS; TOLL-LIKE RECEPTORS; CD8; T-CELLS; DENDRITIC CELLS; LYMPH-NODES; EXPRESSION; NEUTROPHILS; CANCER; TUMOR;

D O I：

10.1007/s12026-009-8119-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.

引用

页码：216 / 226

页数：11

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