Biomonitoring of bisphenol A in hair of Greek population

被引:46
|
作者
Tzatzarakis, Manolis N. [1 ]
Vakonaki, Elena [1 ]
Kawalakis, Matthaios P. [1 ]
Barmpas, Michael [2 ]
Kokkinakis, Emmanouel N. [3 ]
Xenos, Kyriakos [4 ]
Tsatsakis, Aristidis M. [1 ]
机构
[1] Univ Crete, Sch Med, Ctr Toxicol Sci & Res, Iraklion 71003, Crete, Greece
[2] Alexandra Hosp, Dept Gynecol, Athens, Greece
[3] Technol Educ Inst Crete, Food Qual Lab, Lerapetra, Greece
[4] Univ Athens, A Sygros Hosp, Dept Dermatol 1, Athens, Greece
关键词
Hair; Bisphenol A; LC-APCI-MS; Biomonitoring; MASS-SPECTROMETRY METHOD; BPA; EXPOSURE; URINE; ENDOCRINE; MIGRATION; COATINGS; DISEASE; FOOD;
D O I
10.1016/j.chemosphere.2014.10.044
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Objective: Bisphenol A (BPA) is considered as an endocrine-disruptor in which humans are exposed daily mainly by food-contact products, toys, recycled paper and drinking containers. In this study, we validated a method for the isolation and the detection of BPA in human head hair samples and estimated the burden of BPA in hair of Greek population. Methods: Hair samples were collected from 69 volunteers. The isolation of the BPA was performed by solid-liquid extraction with methanol and its determination by a liquid chromatography-mass spectrometry technique. Results: The limits of quantification (LOQ= 9.7 pg mg(-1)), the accuracy (92.6%), the precision (inter 15.3%, intra 13.0%), the ion suppression (<8.1%) and the recovery (88.3%) of the method were found satisfactory. Differences in the detection rates of the positive samples as well in detected levels of BPA between rural and urban population were observed. The 41.2% of the samples collected from urban population were positive whereas the positive samples from rural population were 14.8% (p = 0.025). The mean concentration of the positive samples for the urban population was 64.1 pg mg(-1) (17.7-192.8 pg mg(-1)), for the rural population 40.3 pg mg(-1) (13.1-72.8 pg mg(-1)) and for the children 37.9 pg mg(-1) (13.1-72.8 pg mg(-1)). Significant statistical differences (p = 0.021) were observed though between urban and rural population only when negative samples were replaced with LOD/2 values. Conclusion: The proposed method was successfully applied for the determination of BPA in hair for the estimation of the population burden to BPA. (c) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:336 / 341
页数:6
相关论文
共 50 条
  • [21] Exposure assessment to bisphenol A (BPA) in Portuguese children by human biomonitoring
    Correia-Sa, Luisa
    Kasper-Sonnenberg, Monika
    Schuetze, Andre
    Paelmke, Claudia
    Norberto, Sonia
    Calhau, Conceicao
    Domingues, Valentina F.
    Koch, Holger M.
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2017, 24 (35) : 27502 - 27514
  • [22] Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A
    Andra, Syam S.
    Charisiadis, Pantelis
    Arora, Manish
    van Vliet-Ostaptchouk, Jana V.
    Makris, Konstantinos C.
    ENVIRONMENT INTERNATIONAL, 2015, 85 : 352 - 379
  • [23] Body of Proof Biomonitoring Data Reveal Widespread Bisphenol A Exposures
    Betts, Kellyn S.
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2010, 118 (08) : A353 - A353
  • [24] Exposure assessment to bisphenol A (BPA) in Portuguese children by human biomonitoring
    Luísa Correia-Sá
    Monika Kasper-Sonnenberg
    André Schütze
    Claudia Pälmke
    Sónia Norberto
    Conceição Calhau
    Valentina F. Domingues
    Holger M. Koch
    Environmental Science and Pollution Research, 2017, 24 : 27502 - 27514
  • [25] Biomonitoring of mercury exposure with single human hair strand
    Legrand, M
    Passos, CJS
    Mergler, D
    Chan, HM
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (12) : 4594 - 4598
  • [26] Rapid biomonitoring of heterocyclic aromatic amines in human hair
    Bessette, Erin
    Yasa, Isil
    Wilkens, Lynne
    Le Marchand, Loic
    Turesky, Robert
    CANCER RESEARCH, 2009, 69
  • [27] Instrumental recording and biomonitoring of ambient ozone in the Greek countryside
    Saitanis, CJ
    Karandinos, MG
    CHEMOSPHERE, 2001, 44 (04) : 813 - 821
  • [28] Biomonitoring of Mercury in Hair among a Group of Eritreans (Africa)
    Astolfi, Maria Luisa
    Protano, Carmela
    Marconi, Elisabetta
    Massimi, Lorenzo
    Piamonti, Daniel
    Brunori, Marco
    Vitali, Matteo
    Canepari, Silvia
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020, 17 (06)
  • [29] Biomonitoring of mercury exposure using single hair strands
    Legrand, M
    Lam, R
    Salin, E
    Passos, CJS
    Mergler, D
    Chan, HM
    EPIDEMIOLOGY, 2005, 16 (05) : S158 - S158
  • [30] Monitoring of bisphenol A and S in hair during pregnancy
    Vakonaki, E.
    Tzatzarakis, M.
    Flamourakis, M.
    Koukakis, M.
    Fragkiadoulaki, I.
    Karzi, V.
    Kavvalakis, M.
    Alegkakis, A.
    Renieri, E.
    Fragkiadaki, P.
    Hatzidaki, E.
    Vardavas, A.
    Tsatsakis, A.
    TOXICOLOGY LETTERS, 2024, 399 : S333 - S333