Molecular imaging of alcoholic liver disease with phosphodiesterase (PDE) 4B targeted [18F]PF-06445974 and positron emission tomography

被引:0
|
作者
Shao, Tuo [1 ]
Chen, Jiahui [2 ]
Liang, Steven [1 ]
机构
[1] Harvard, MGH, Boston, MA USA
[2] Massachusetts Gen Hosp, Boston, MA 02114 USA
关键词
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
SSP-09
引用
收藏
页码:S18 / S18
页数:1
相关论文
共 50 条
  • [1] Evaluation in rat, monkey, and humans of [18F]PF-06445974, a PET radioligand for phosphodiesterase 4B
    Wakabayashi, Yuichi
    Stenkrona, Per
    Liow, Jeih-San
    Maresca, Kevin P.
    Chappie, Thomas A.
    Zhang, Lei
    Hughes, Zo E. A.
    Schmidt, Christopher J.
    Doran, Shawn D.
    Arakawa, Ryosuke
    Varrone, Andrea
    Takano, Akihiro
    Fregonara, Paolo Z.
    Zoghbi, Sami S.
    Ooms, Maarten
    Morse, Cheryl
    Pike, Victor W.
    Halldin, Christer
    Innis, Robert B.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2021, 41 (1_SUPPL): : 105 - 106
  • [2] Monkey, rat, and first in human evaluation of [18F]PF-06445974, a PET radioligand that preferentially labels phosphodiesterase 4B
    Wakabayashi, Yuichi
    Liow, Jeih-San
    Maresca, Kevin
    Chappie, Thomas
    Zhang, Lei
    Hughes, Zoe
    Schmidt, Christopher
    Doran, Shawn
    Fregonara, Paolo
    Zoghbi, Sami
    Ooms, Maarten
    Morse, Cheryl
    Pike, Victor
    Innis, Robert
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62
  • [3] Novel PET Radioligand [18 F]PF-06445974 Can Measure LPS-Induced Phosphodiesterase 4B in Rat Brain
    Parcon, Paul
    Liow, Jeih-San
    Wu, Shawn
    Morse, Cheryl
    Knoer, Carson
    Pike, Victor
    Innis, Robert
    NEUROPSYCHOPHARMACOLOGY, 2022, 47 : 511 - 511
  • [4] In Vivo Evaluation of [18F] PF-06445974, a Novel Phosphodiesterase 4D Sparing PET Radioligand for the Phosphodiesterase 4 Enzyme, In Nonhuman Primates
    Chen, L.
    Zasadny, K.
    Beck, E. M.
    Chang, C.
    Chappie, T.
    Coelho, R. V.
    Doran, S.
    Fan, K.
    Kuszpit, K.
    Skaddan, M. B.
    Villalobos, A.
    Young, J. M.
    Zhang, L.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2016, 43 : S97 - S97
  • [5] [18F]PF-06445974 Pet Ligand Can Measure LPS-Mediated Changes in PDE4B in Rat Brain: A Comparison With TSPO
    Parcon, Paul
    Knoer, Carson
    Zoghbi, Sami
    Liow, Jeih-San
    Morse, Cheryl
    Pike, Victor
    Innis, Robert
    NEUROPSYCHOPHARMACOLOGY, 2023, 48 : 69 - 70
  • [6] Molecular imaging of proliferation in vivo: Positron emission tomography with [18F]fluorothymidine
    Buck, Andreas K.
    Herrmann, Ken
    Shen, Changxian
    Dechow, Tobias
    Schwaiger, Markus
    Wester, Hans-Juergen
    METHODS, 2009, 48 (02) : 205 - 215
  • [7] Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography
    Scherer, Daniel J.
    Psaltis, Peter J.
    CARDIOVASCULAR DIAGNOSIS AND THERAPY, 2016, 6 (04) : 354 - 367
  • [8] Development of a novel 18F-labeled PET ligand for imaging phosphodiesterase (PDE) 4B
    Chen, Jiahui
    Shao, Tuo
    Sun, Shaofa
    Liang, Steven
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62
  • [9] Molecular imaging of Nonalcoholic steatohepatitis (NASH) with Autotaxin-targeted [18F]ATX-1905 and Positron Emission Tomography
    Shao, Tuo
    Deng, Xiaoyun
    Liang, Steven
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62
  • [10] The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
    Zhang, Lei
    Chen, Laigao
    Beck, Elizabeth M.
    Chappie, Thomas A.
    Coelho, Richard V.
    Doran, Shawn D.
    Fan, Kuo-Hsien
    Helal, Christopher J.
    Humphrey, John M.
    Hughes, Zoe
    Kuszpit, Kyle
    Lachapelle, Erik A.
    Lazzaro, John T.
    Lee, Chewah
    Mather, Robert J.
    Patel, Nandini C.
    Skaddan, Marc B.
    Sciabola, Simone
    Verhoest, Patrick R.
    Young, Joseph M.
    Zasadny, Kenneth
    Villalobos, Anabella
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (20) : 8538 - 8551