In Vivo Evaluation of [18F] PF-06445974, a Novel Phosphodiesterase 4D Sparing PET Radioligand for the Phosphodiesterase 4 Enzyme, In Nonhuman Primates

被引:0
|
作者
Chen, L. [1 ]
Zasadny, K. [1 ]
Beck, E. M. [1 ]
Chang, C. [1 ]
Chappie, T. [2 ]
Coelho, R. V. [1 ]
Doran, S. [1 ]
Fan, K. [1 ]
Kuszpit, K. [1 ]
Skaddan, M. B. [1 ]
Villalobos, A. [2 ]
Young, J. M. [1 ]
Zhang, L. [2 ]
机构
[1] Pfizer Inc, Worldwide Res & Dev, Groton, CT 06340 USA
[2] Pfizer Inc, Worldwide Res & Dev, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OP310
引用
收藏
页码:S97 / S97
页数:1
相关论文
共 50 条
  • [1] Evaluation in rat, monkey, and humans of [18F]PF-06445974, a PET radioligand for phosphodiesterase 4B
    Wakabayashi, Yuichi
    Stenkrona, Per
    Liow, Jeih-San
    Maresca, Kevin P.
    Chappie, Thomas A.
    Zhang, Lei
    Hughes, Zo E. A.
    Schmidt, Christopher J.
    Doran, Shawn D.
    Arakawa, Ryosuke
    Varrone, Andrea
    Takano, Akihiro
    Fregonara, Paolo Z.
    Zoghbi, Sami S.
    Ooms, Maarten
    Morse, Cheryl
    Pike, Victor W.
    Halldin, Christer
    Innis, Robert B.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2021, 41 (1_SUPPL): : 105 - 106
  • [2] Monkey, rat, and first in human evaluation of [18F]PF-06445974, a PET radioligand that preferentially labels phosphodiesterase 4B
    Wakabayashi, Yuichi
    Liow, Jeih-San
    Maresca, Kevin
    Chappie, Thomas
    Zhang, Lei
    Hughes, Zoe
    Schmidt, Christopher
    Doran, Shawn
    Fregonara, Paolo
    Zoghbi, Sami
    Ooms, Maarten
    Morse, Cheryl
    Pike, Victor
    Innis, Robert
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62
  • [3] Novel PET Radioligand [18 F]PF-06445974 Can Measure LPS-Induced Phosphodiesterase 4B in Rat Brain
    Parcon, Paul
    Liow, Jeih-San
    Wu, Shawn
    Morse, Cheryl
    Knoer, Carson
    Pike, Victor
    Innis, Robert
    NEUROPSYCHOPHARMACOLOGY, 2022, 47 : 511 - 511
  • [4] First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B
    Wakabayashi, Yuichi
    Stenkrona, Per
    Arakawa, Ryosuke
    Yan, Xuefeng
    Van Buskirk, Maia G.
    Jenkins, Madeline D.
    Santamaria, Jose A. Montero
    Maresca, Kevin P.
    Takano, Akihiro
    Liow, Jeih-San
    Chappie, Thomas A.
    Varrone, Andrea
    Nag, Sangram
    Zhang, Lei
    Hughes, Zoe A.
    Schmidt, Christopher J.
    Doran, Shawn D.
    Mannes, Andrew
    Zanotti-Fregonara, Paolo
    Ooms, Maarten
    Morse, Cheryl L.
    Zoghbi, Sami S.
    Halldin, Christer
    Pike, Victor W.
    Innis, Robert B.
    JOURNAL OF NUCLEAR MEDICINE, 2022, 63 (12) : 1919 - 1924
  • [5] Molecular imaging of alcoholic liver disease with phosphodiesterase (PDE) 4B targeted [18F]PF-06445974 and positron emission tomography
    Shao, Tuo
    Chen, Jiahui
    Liang, Steven
    NUCLEAR MEDICINE AND BIOLOGY, 2021, 96-97 : S18 - S18
  • [6] Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme
    Chen, Laigao
    Nabulsi, Nabeel
    Naganawa, Mika
    Zasadny, Kenneth
    Skaddan, Marc B.
    Zhang, Lei
    Najafzadeh, Soheila
    Lin, Shu-fei
    Helal, Christopher J.
    Boyden, Tracey L.
    Chang, Cheng
    Ropchan, Jim
    Carson, Richard E.
    Villalobos, Anabella
    Huang, Yiyun
    JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (09) : 1448 - 1453
  • [7] Syntheses and Evaluation of Phosphodiesterase Subtype 4D (PDE4D) PET Radioligand Candidates in Monkey
    Telu, Sanjay
    Fujita, Masahiro
    Wakabayashi, Yuichi
    Dick, Rachel
    Liow, Jeih-San
    Hong, Jinsoo
    Morse, Cheryl
    Ooms, Maarten
    Zoghbi, Sami
    Mo, Xuesheng
    Gladding, Robert
    Nugent, Richard
    Gurney, Mark
    Innis, Robert
    Pike, Victor
    JOURNAL OF NUCLEAR MEDICINE, 2020, 61
  • [8] Evaluation of a novel phosphodiesterase (PDE) 4B PET radioligand [18F]P4B-1903 in neuroinflammation mouse model
    Chen, Jiahui
    Zhou, Xin
    Li, Yinlong
    Gao, Yabiao
    Patel, Jimmy
    Crowe, Ronald
    Haider, Ahmed
    Yuan, Hongjie
    Liang, Steven
    JOURNAL OF NUCLEAR MEDICINE, 2024, 65
  • [9] Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates
    Haider, Ahmed
    Wang, Lu
    Gobbi, Luca
    Li, Yinlong
    Chaudhary, Ahmad
    Zhou, Xin
    Chen, Jiahui
    Zhao, Chunyu
    Rong, Jian
    Xiao, Zhiwei
    Hou, Lu
    Elghazawy, Nehal H.
    Sippl, Wolfgang
    Davenport, April T.
    Daunais, James B.
    Ahmed, Hazem
    Crowe, Ron
    Honer, Michael
    Rominger, Axel
    Grether, Uwe
    Liang, Steven H.
    Ametamey, Simon M.
    ACS CHEMICAL NEUROSCIENCE, 2023, 14 (20): : 3752 - 3760
  • [10] Novel PET radioligand [18F]PF-06445974 targets PDE4B, and its uptake is rapidly increased by LPS-induced neuroinflammation compared to TSPO radioligand [11C]ER176
    Parcon, Paul
    Cureton, Raven
    Scrabis, Mia
    Knoer, Carson
    Zoghbi, Sami
    Morse, Cheryl
    Liow, Jeih-San
    Wu, Shawn
    Pike, Victor
    Innis, Robert
    JOURNAL OF NUCLEAR MEDICINE, 2024, 65