Difluoroalkylation/1,2-aryl migration of allylic alcohols under transition metal-free conditions

被引：4
|
作者：
Ge, Danhua [1 ]
Wang, Xin [2 ]
Chu, Xue-Qiang [1 ]
机构：
[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Peoples R China
[2] Hubei Prov Geol Expt Testing Ctr, Wuhan 430034, Hubei, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 70卷
基金：
中国国家自然科学基金;
关键词：
Radical reaction; Difluoroalkylation; 1,2-Aryl migration; Allylic alcohols; Sodium hydrosulfite; RECENT PROGRESS; FUNCTIONALIZATION; FLUORINE;
D O I：
10.1016/j.tetlet.2021.153002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile difluoroalkylation and 1,2-aryl migration reaction commencing from allylic alcohols and simple BrCF2COOEt was developed. This metal-free method offers chemists green and efficient access to important difluoro 1,5-dicarbonyl compounds in moderate to good yields with good functional group tolerance. Sodium hydrosulfite was used as a low-toxic, cheap, environmentally friendly, and efficient radical initiator. The feasibility of performing the transformation on a large scale potentially allows the further application of the present method in other fields. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：4
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