Inhibiting the nuclear exporter XPO1 and the antiapoptotic factor BCL2 is synergistic in XPO1 and SF3B1 mutant hematologic malignancies.

被引:0
|
作者
Totiger, Tulasigeri M. [1 ]
Chaudhry, Sana [1 ]
Afaghani, Jumana [1 ]
Taylor, Justin [1 ]
机构
[1] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1341
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1
    Noguchi, E
    Saitoh, YH
    Sazer, S
    Nishimoto, T
    JOURNAL OF BIOCHEMISTRY, 1999, 125 (03): : 574 - 585
  • [42] Proteomics identify nuclear export as a targetable pathway in neuroblastoma: Comment on "XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IκB"
    Shah, Nilay
    TRANSLATIONAL ONCOLOGY, 2021, 14 (08):
  • [43] XPO1 inhibition displays anti-leukemia efficacy against DNMT3A-mutant acute myeloid leukemia via downregulating glutathione pathway
    Cai, Xiaoya
    Liu, Ying
    Li, Huimin
    Que, Yimei
    Xiao, Min
    Wang, Ying
    Wang, Xiong
    Li, Dengju
    ANNALS OF HEMATOLOGY, 2024, 103 (05) : 1803 - 1803
  • [44] Selective inhibitor of nuclear exporter CRM1/XPO1, Selinexor (KPT-330), exhibits remarkable activity against AML leukemia-initiating cells while sparing normal hematopoietic cells
    Etchin, Julia
    Le, Bonnie Thi
    Berezovskaya, Alla
    Conway, Amy S.
    Chen, Weihsu C.
    Kentsis, Alex
    Mansour, Marc R.
    Stone, Richard M.
    Galinsky, Ilene A.
    DeAngelo, Daniel J.
    McCauley, Dilara
    Kauffman, Michael
    Shacham, Sharon
    Wang, Jean C. Y.
    Kung, Andrew L.
    Look, Thomas
    CANCER RESEARCH, 2015, 75
  • [45] SL-401, a Targeted Therapy Directed to the Interleukin-3 Receptor (CD123), and SL-801, a Reversible Inhibitor of Exportin-1 (XPO1), Display Synergistic Anti-Tumor Activity Against Hematologic Malignancies in Vitro
    Gionco, John
    Chen, Janice
    Lindsay, Ross
    Macri, Vince
    Brooks, Christopher L.
    BLOOD, 2016, 128 (22)
  • [46] Combinatorial Targeting of XPO1 and FLT3-ITD Exerts Synergistic Anti-Tumor Effects in FLT3-Mutated Acute Myeloid Leukemias
    Zhang, Weiguo
    Ishizawa, Jo
    Mu, Hong
    Daver, Naval
    Ruvolo, Vivian
    Andreeff, Michael
    BLOOD, 2015, 126 (23)
  • [47] Phase Ib/II study of the IDH1-mutant inhibitor ivosidenib with the BCL2 inhibitor venetoclax plus /- azacitidine in IDH1-mutated hematologic malignancies.
    Lachowiez, Curtis Andrew
    Borthakur, Gautam
    Loghavi, Sanam
    Zeng, Zhihong
    Kadia, Tapan M.
    Masarova, Lucia
    Takahashi, Koichi
    Tippett, George Dono
    Naqvi, Kiran
    Bose, Prithviraj
    Jabbour, Elias
    Ravandi, Farhad
    Daver, Naval Guastad
    Garcia-Manero, Guillermo
    Stoilova, Bilyana
    Vyas, Paresh
    Kantarjian, Hagop M.
    Konopleva, Marina
    Dinardo, Courtney Denton
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [48] Synergistic effects of the combination of Kras (G12C) with SHP2, ERK 1/2, mTORC1/2 or XPO1 inhibition for the treatment of Kras (G12C) mutated cancer
    Wang, Jian
    Chen, Peng
    Kong, Ya
    Hui Yuwen
    Jiang, Bin
    Tian, Linjie
    Hou, Bing
    Mei, Jay
    Shan, Bo
    CANCER RESEARCH, 2022, 82 (12)
  • [49] Cooperative Somatic Alterations in XPO1 and TNFAIP3 (A20) Promote Immune Modulation and Tissue Infiltration in Primary Mediastinal B Cell Lymphoma
    Whipp, Ethan C.
    Walker, Janek S.
    Gharghabi, Mehdi
    Cempre, Casey
    Walker, Brandi
    Lapalombella, Rosa
    BLOOD, 2023, 142
  • [50] Gene Expression and Transcription Factor (TF) Activation Profiling Identifies Suppression of Multiple Myeloma (MM) Cell Survival and Chemoresistance Pathways By Inhibition of XPO1/CRM1-Dependent Nuclear Export with Selinexor
    Rosebeck, Shaun
    Alonge, Mattina
    Jasielec, Jagoda
    Mayampurath, Anoop
    Volchenboum, Samuel L.
    Shacham, Sharon
    Kauffman, Michael
    Jakubowiak, Andrzej
    BLOOD, 2014, 124 (21)