Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study

被引：16

作者：

Hendrix, James A. ^{[1
]}

Airey, David C. ^{[2
]}

Britton, Angela ^{[1
]}

Burke, Anna D. ^{[3
,4
]}

Capone, George T. ^{[5
]}

Chavez, Ronelyn ^{[6
]}

Chen, Jacqueline ^{[7
]}

Chicoine, Brian ^{[8
]}

Costa, Alberto C. S. ^{[9
]}

Dage, Jeffrey L. ^{[2
]}

Doran, Eric ^{[10
]}

Esbensen, Anna ^{[11
,12
]}

Evans, Casey L. ^{[13
]}

Faber, Kelley M. ^{[14
,16
]}

Foroud, Tatiana M. ^{[14
]}

Hart, Sarah ^{[15
]}

Haugen, Kelsey

Head, Elizabeth ^{[17
]}

Hendrix, Suzanne ^{[18
]}

Hillerstrom, Hampus ^{[1
]}

Kishnani, Priya S. ^{[15
]}

Krell, Kavita ^{[16
]}

Ledesma, Duvia Lara ^{[6
]}

Lai, Florence ^{[19
,20
]}

Lott, Ira ^{[10
]}

Ochoa-Lubinoff, Cesar ^{[7
]}

Mason, Jennifer ^{[6
]}

Nicodemus-Johnson, Jessie ^{[18
]}

Proctor, Nicholas Kyle ^{[2
]}

Pulsifer, Margaret B. ^{[13
]}

Revta, Carolyn ^{[6
]}

Rosas, H. Diana ^{[19
,20
]}

Rosser, Tracie C. ^{[21
]}

Santoro, Stephanie ^{[16
,22
]}

Schafer, Kim ^{[6
]}

Scheidemantel, Thomas ^{[23
]}

Schmitt, Frederick ^{[24
]}

Skotko, Brian G. ^{[16
,22
]}

Stasko, Melissa R. ^{[23
]}

Talboy, Amy ^{[25
]}

Torres, Amy ^{[16
]}

Wilmes, Kristi ^{[14
]}

Woodward, Jason ^{[11
,12
]}

Zimmer, Jennifer A. ^{[2
]}

Feldman, Howard H. ^{[6
]}

Mobley, William ^{[26
]}

机构：

[1] LuMind IDSC, 20 Mall Rd,Suite 200, Burlington, MA 01803 USA

[2] Eli Lilly & Co, 893 Delaware St, Indianapolis, IN 46225 USA

[3] St Josephs Hosp, 350 W Thomas Rd, Phoenix, AZ 85013 USA

[4] Barrow Neurol Inst, Med Ctr, Dept Neurol, 350 W Thomas Rd, Phoenix, AZ 85013 USA

[5] Kennedy Krieger Inst, Down Syndrome Clin & Res Ctr, 707 N Broadway, Baltimore, MD 21205 USA

[6] Univ Calif San Diego, Alzheimers Dis Cooperat Study, Dept Neurosci, 9500 Gilman Dr, La Jolla, CA 92093 USA

[7] Rush Univ, Med Ctr, Div Dev Behav Pediat, Dept Pediat, 1653 W Congress Pkwy, Chicago, IL 60612 USA

[8] Advocate Med Grp, Adult Down Syndrome Ctr, 1610 Luther Lane, Park Ridge, IL 60068 USA

[9] Case Western Reserve Univ, Sch Med, Div Neurol & Epilepsy, Dept Pediat,Dept Psychiat, 10524 Euclid Ave, Cleveland, OH 44106 USA

[10] Univ Calif Irvine, Dept Pediat, 333 City Blvd West,Suite 800, Orange, CA 92868 USA

[11] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229 USA

[12] Cincinnati Childrens Hosp Med Ctr, Div Dev & Behav Pediat, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[13] Massachusetts Gen Hosp, Dept Psychiat, 55 Fruit St, Boston, MA 02114 USA

[14] Indiana Univ Sch Med, Natl Centralized Repository Alzheimers Dis & Rela, 410 W 10th St, Indianapolis, IN 46202 USA

[15] Duke Univ, Med Ctr, Dept Pediat, 2301 Erwin Rd, Durham, NC 27705 USA

[16] Massachusetts Gen Hosp, Down Syndrome Program, Div Med Genet & Metab, Dept Pediat, 55 Fruit St, Boston, MA 02114 USA

[17] Univ Calif Irvine, Sch Med, Dept Pathol & Lab Med, 1111 Gillepsie Neurosci Res Facil, Irvine, CA 92697 USA

[18] Pentara Corp, 2261 East 3300 South,Suite 200, Millcreek, UT 84109 USA

[19] Massachusetts Gen Hosp, McLean Hosp, Dept Neurol, 55 Fruit St, Boston, MA 02114 USA

[20] Harvard Med Sch, 55 Fruit St, Boston, MA 02114 USA

[21] Emory Univ, Dept Human Genet, 615 Michael St,Suite 301, Atlanta, GA 30322 USA

[22] Harvard Med Sch, Dept Pediat, 25 Shattuck St, Boston, MA 02115 USA

[23] Case Western Reserve Univ, Sch Med, Univ Hosp Cleveland, Med Ctr,Dept Psychiat, 10524 Euclid Ave, Cleveland, OH 44106 USA

[24] Univ Kentucky, Sanders Brown Ctr Aging, 800 S Limestone St, Lexington, KY 40536 USA

[25] Emory Univ, Sch Med, Dept Human Genet, 1365 Clifton Rd NE,Bldg A,Suite 2200, Atlanta, GA 30322 USA

[26] Univ Calif San Diego, Dept Neurosci, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 09期

关键词：

Down syndrome; Alzheimer’ s disease; blood biomarkers; phosphorylated tau protein; amyloid β peptide; neurofilament light chain; glial fibrillary acidic protein; ADULTS; DEMENTIA;

D O I：

10.3390/jcm10091907

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer's disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recruiting 270 adults with DS over the age of 25. The study is designed to characterize trajectories of change in DS-associated AD (DS-AD). The current study reports its cross-sectional analysis of the first 90 subjects enrolled. Plasma biomarkers phosphorylated tau protein (p-tau), neurofilament light chain (NfL), amyloid beta peptides (A beta(1-40), A beta(1-42)), and glial fibrillary acidic protein (GFAP) were undertaken with previously published methods. The clinical data from the baseline visit include demographics as well as the cognitive measures under the Severe Impairment Battery (SIB) and Down Syndrome Mental Status Examination (DS-MSE). Biomarker distributions are described with strong statistical associations observed with participant age. The biomarker data contributes to understanding DS-AD across the spectrum of disease. Collectively, the biomarker data show evidence of DS-AD progression beginning at approximately 40 years of age. Exploring these data across the full LIFE-DSR longitudinal study population will be an important resource in understanding the onset, progression, and clinical profiles of DS-AD pathophysiology.

引用

页数：11

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