Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer's disease in adults with Down syndrome

被引：2

作者：

Videla, Laura ^{[1
,2
,3
]}

Benejam, Bessy

Carmona-Iragui, Maria ^{[1
,2
,3
]}

Barroeta, Isabel ^{[1
,3
]}

Fernandez, Susana ^{[2
]}

Arranz, Javier ^{[1
]}

Elbachiri Azzahchi, Sumia ^{[1
]}

Altuna, Miren ^{[1
,3
,4
]}

Padilla, Concepcion ^{[1
]}

Valldeneu, Silvia ^{[1
,3
]}

Pegueroles, Jordi ^{[1
,3
]}

Montal, Victor ^{[1
,3
]}

Rozalem Aranha, Mateus ^{[1
]}

Vaque-Alcazar, Lidia ^{[1
,5
,6
]}

Florencia Iulita, Maria ^{[1
]}

Alcolea, Daniel ^{[1
,3
]}

Bejanin, Alexandre ^{[1
,3
]}

Videla, Sebastia ^{[7
]}

Blesa, Rafael ^{[1
,3
]}

Lleo, Alberto ^{[1
,3
]}

Fortea, Juan ^{[1
,2
,3
]}

机构：

[1] Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain

[2] Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain

[3] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

[4] CITA Alzheimer Fdn, Donostia San Sebsatian, Spain

[5] Univ Barcelona, Fac Med & Hlth Sci, Dept Med, Inst Neurosci, Barcelona, Spain

[6] Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain

[7] Univ Barcelona, Bellvitge Univ Hosp, Clin Res Support Unit HUB IDIBELL, Clin Pharmacol Dept, Barcelona, Spain

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Alzheimer disease; CAMCOG-DS; cognition; cognitive decline; Down syndrome; mCRT; INTELLECTUAL DISABILITIES; DEMENTIA; CRITERIA; DECLINE;

D O I：

10.1002/alz.13073

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD). However, clinical diagnosis is difficult, and experts emphasize the need for detecting intra-individual cognitive decline. Objective: To compare the performance of baseline and longitudinal neuropsychological assessments for the diagnosis of symptomatic AD in DS. Methods: Longitudinal cohort study of adults with DS. Individuals were classified as asymptomatic, prodromal AD, or AD dementia. We performed receiver operating characteristic curve analyses to compare baseline and longitudinal changes of CAMCOG-DS and mCRT. Results: We included 562 adults with DS. Baseline assessments showed good to excellent diagnostic performance for AD dementia (AUCs between 0.82 and 0.99) and prodromal AD, higher than the 1-year intra-individual cognitive decline (area under the ROC curve between 0.59 and 0.79 for AD dementia, lower for prodromal AD). Longer follow-ups increased the diagnostic performance of the intra-individual cognitive decline. Discussion: Baseline cognitive assessment outperforms the 1-year intra-individual cognitive decline in adults with DS.

引用

页码：3916 / 3925

页数：10

共 50 条

[1] Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study
Fortea, Juan
Carmona-Iragui, Maria
Benejam, Bessy
Fernandez, Susana
Videla, Laura
Barroeta, Isabel
Alcolea, Daniel
Pegueroles, Jordi
Munoz, Laia
Belbin, Olivia
de Leon, Mony J.
Maleska Maceski, Aleksandra
Hirtz, Christophe
Clarimon, Jordi
Videla, Sebastian
Delaby, Constance
Lehmann, Sylvain
Blesa, Rafael
Lleo, Alberto
LANCET NEUROLOGY, 2018, 17 (10): : 860 - 869
[2] Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study
Fortea, Juan
Vilaplana, Eduard
Carmona-Iragui, Maria
Benejam, Bessy
Videla, Laura
Barroeta, Isabel
Fernandez, Susana
Altuna, Miren
Pegueroles, Jordi
Montal, Victor
Valldeneu, Silvia
Gimenez, Sandra
Gonzalez-Ortiz, Sofia
Munoz, Laia
Estelles, Teresa
Illan-Gala, Ignacio
Belbin, Olivia
Camacho, Valle
Wilson, Liam Reese
Annus, Tiina
Osorio, Ricardo S.
Videla, Sebastian
Lehmann, Sylvain
Holland, Anthony J.
Alcolea, Daniel
Clarimon, Jordi
Zaman, Shahid H.
Blesa, Rafael
Lleo, Alberto
LANCET, 2020, 395 (10242): : 1988 - 1997
[3] Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study
Boerwinkle, Anna H.
Gordon, Brian A.
Wisch, Julie
Flores, Shaney
Henson, Rachel L.
Butt, Omar H.
McKay, Nicole
Chen, Charles D.
Benzinger, Tammie L. S.
Fagan, Anne M.
Handen, Benjamin L.
Christian, Bradley T.
Head, Elizabeth
Mapstone, Mark
Rafii, Michael S.
O'Bryant, Sid
Lai, Florence
Rosas, H. Diana
Lee, Joseph H.
Silverman, Wayne
Brickman, Adam M.
Chhatwal, Jasmeer P.
Cruchaga, Carlos
Perrin, Richard J.
Xiong, Chengjie
Hassenstab, Jason
McDade, Eric
Bateman, Randall J.
Ances, Beau M.
LANCET NEUROLOGY, 2023, 22 (01): : 55 - 65
[4] AGE, ADAPTIVE-BEHAVIOR, AND ALZHEIMER-DISEASE IN DOWN-SYNDROME - CROSS-SECTIONAL AND LONGITUDINAL ANALYSES
RASMUSSEN, DE
SOBSEY, D
AMERICAN JOURNAL ON MENTAL RETARDATION, 1994, 99 (02): : 151 - 165
[5] Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study
Wisch, Julie K.
McKay, Nicole S.
Boerwinkle, Anna H.
Kennedy, James
Flores, Shaney
Handen, Benjamin L.
Christian, Bradley T.
Head, Elizabeth
Mapstone, Mark
Rafii, Michael S.
O'Bryant, Sid E.
Price, Julie C.
Laymon, Charles M.
Krinsky-McHale, Sharon J.
Lai, Florence
Rosas, H. Diana
Hartley, Sigan L.
Zaman, Shahid
Lott, Ira T.
Tudorascu, Dana
Zammit, Matthew
Brickman, Adam M.
Lee, Joseph H.
Bird, Thomas D.
Cohen, Annie
Chrem, Patricio
Daniels, Alisha
Chhatwal, Jasmeer P.
Cruchaga, Carlos
Ibanez, Laura
Jucker, Mathias
Karch, Celeste M.
Day, Gregory S.
Lee, Jae-Hong
Levin, Johannes
Llibre-Guerra, Jorge
Li, Yan
Lopera, Francisco
Roh, Jee Hoon
Ringman, John M.
Supnet-Bell, Charlene
van Dyck, Christopher H.
Xiong, Chengjie
Wang, Guoqiao
Morris, John C.
McDade, Eric
Bateman, Randall J.
Benzinger, Tammie L. S.
Gordon, Brian A.
Ances, Beau M.
LANCET NEUROLOGY, 2024, 23 (05): : 500 - 510
[6] Cross-sectional versus longitudinal performance assessments in the management of diabetes
Weiner, M
Long, J
MEDICAL CARE, 2004, 42 (02) : 34 - 39
[7] Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
Leung, Kelvin K.
Barnes, Josephine
Ridgway, Gerard R.
Bartlett, Jonathan W.
Clarkson, Matthew J.
Macdonald, Kate
Schuff, Norbert
Fox, Nick C.
Ourselin, Sebastien
NEUROIMAGE, 2010, 51 (04) : 1345 - 1359
[8] Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study
Fagan, Anne M.
Henson, Rachel L.
Li, Yan
Boerwinkle, Anna H.
Xiong, Chengjie
Bateman, Randall J.
Goate, Alison
Ances, Beau M.
Doran, Eric
Christian, Bradley T.
Lai, Florence
Rosas, H. Diana
Schupf, Nicole
Krinsky-McHale, Sharon
Silverman, Wayne
Lee, Joseph H.
Klunk, William E.
Handen, Benjamin L.
Allegri, Ricardo F.
Chhatwal, Jasmeer P.
Day, Gregory S.
Graff-Radford, Neill R.
Jucker, Mathias
Levin, Johannes
Martins, Ralph N.
Masters, Colin L.
Mori, Hiroshi
Mummery, Catherine J.
Niimi, Yoshiki
Ringman, John M.
Salloway, Stephen
Schofield, Peter R.
Shoji, Mikio
Lott, Ira T.
LANCET NEUROLOGY, 2021, 20 (08): : 615 - 626
[9] ALZHEIMER'S DISEASE IN ADULTS WITH DOWN SYNDROME
Zigman, Warren B.
Devenny, Darlynne A.
Krinsky-McHale, Sharon J.
Jenkins, Edmund C.
Urv, Tiina K.
Wegiel, Jerzy
Schupf, Nicole
Silverman, Wayne
INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL 36, 2008, 36 : 103 - 145
[10] Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer’s disease
Kalicharan Patra
Antoninus Soosaipillai
Sigrid Botne Sando
Camilla Lauridsen
Guro Berge
Ina Møller
Gøril Rolfseng Grøntvedt
Geir Bråthen
Ilijana Begcevic
Simon Moussaud
Lennart Minthon
Oskar Hansson
Eleftherios P. Diamandis
Linda R. White
Henrietta M. Nielsen
Alzheimer's Research & Therapy, 10

← 1 2 3 4 5 →