Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

被引：8
|
作者：
Sahu, Pramod K. [1 ]
Kim, Gyudong [1 ]
Nayak, Akshata [1 ,2 ]
Ahn, Ji Yoon [1 ]
Ha, Min Woo [1 ]
Park, Cheonhyoung [1 ]
Yu, Jinha [1 ]
Park, Hyeung-geun [1 ]
Jeong, Lak Shin [1 ]
机构：
[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Seoul 151742, South Korea
[2] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
acyclic nucleoside phosphonates; antivirals; diselenides; selenoadefovir; selenotenofovir; NUCLEOTIDE ANALOGS; HEPATITIS-B; DERIVATIVES; INFECTIONS; MECHANISM; HIV;
D O I：
10.1002/ajoc.201500421
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.
引用
收藏
页码：183 / 186
页数：4
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