Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

被引：8
|
作者：
Sahu, Pramod K. [1 ]
Kim, Gyudong [1 ]
Nayak, Akshata [1 ,2 ]
Ahn, Ji Yoon [1 ]
Ha, Min Woo [1 ]
Park, Cheonhyoung [1 ]
Yu, Jinha [1 ]
Park, Hyeung-geun [1 ]
Jeong, Lak Shin [1 ]
机构：
[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Seoul 151742, South Korea
[2] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
acyclic nucleoside phosphonates; antivirals; diselenides; selenoadefovir; selenotenofovir; NUCLEOTIDE ANALOGS; HEPATITIS-B; DERIVATIVES; INFECTIONS; MECHANISM; HIV;
D O I：
10.1002/ajoc.201500421
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.
引用
收藏
页码：183 / 186
页数：4
相关论文
共 50 条
  • [1] Synthesis of acyclic nucleoside phosphonates as antiviral compounds
    Wormstädt, F
    Brinckmann, U
    Gütschow, M
    Eger, K
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (05) : 1187 - 1191
  • [2] Research Progress in Prodrugs of Acyclic Nucleoside Phosphonates Antiviral Agents
    Gao, Mengyuan
    Liu, Hongtao
    Lian, Yufei
    Gao, Xinfeng
    Geng, Yunhe
    Li, Wenyan
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 39 (04) : 974 - 981
  • [3] Synthesis and antiviral activities of fluorinated acyclic nucleoside phosphonates
    Chen, W
    Flavin, MT
    Filler, R
    Xu, ZQ
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (23): : 3979 - 3988
  • [4] SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES FOR EVALUATION AS ANTIVIRAL AGENTS
    REIST, EJ
    STURM, PA
    PONG, RY
    TANGA, MJ
    SIDWELL, RW
    NUCLEOTIDE ANALOGUES AS ANTIVIRAL AGENTS, 1989, 401 : 17 - 34
  • [5] SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES FOR EVALUATION AS ANTIVIRAL AGENTS
    REIST, EJ
    STURM, PA
    PONG, RY
    TANGA, MJ
    SIDWELL, RW
    ACS SYMPOSIUM SERIES, 1989, 401 : 17 - 34
  • [6] Simple synthesis of novel acyclic (E)-bromovinyl nucleosides as potential antiviral agents
    Kim, Jin Woo
    Hong, Joon Hee
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2006, 25 (08): : 879 - 887
  • [7] SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES AS ANTIVIRAL AGENTS AGAINST CYTOMEGALOVIRUS
    REIST, EJ
    BRADFORD, WW
    HUFFMAN, J
    SIDWELL, RW
    RUHLANDFRITSCH, BL
    STURM, PA
    ZAVERI, NT
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1994, 13 (1-3): : 539 - 550
  • [8] Antiviral activity of acyclic and cyclic nucleoside phosphonates
    De Clercq, E.
    JOURNAL OF CLINICAL VIROLOGY, 2009, 46 : S1 - S1
  • [9] Synthesis of New Cyclic and Acyclic 5-Halouridine Derivatives as Potential Antiviral Agents
    Elshehry, Mohamed F.
    Balzarini, Jan
    Meier, Chris
    SYNTHESIS-STUTTGART, 2009, (05): : 841 - 847
  • [10] SYNTHESIS OF C-6 PYRIMIDINE ACYCLIC NUCLEOSIDE ANALOGS AS POTENTIAL ANTIVIRAL AGENTS
    HSU, LY
    WISE, DS
    SHANNON, WM
    DRACH, JC
    TOWNSEND, LB
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1994, 13 (1-3): : 563 - 584
12345