Gold-Catalyzed Intermolecular [4+2] Annulation of 2-Ethynylanilines with Ynamides: An Access to Substituted 2-Aminoquinolines

被引：36
|
作者：
Zhao, Ximei [1 ]
Song, Xinlong [1 ]
Jin, Hongming [1 ]
Zeng, Zhongyi [1 ]
Wang, Qian [1 ]
Rudolph, Matthias [1 ]
Rominger, Frank [1 ]
Hashmi, A. Stephen K. [1 ,2 ]
机构：
[1] Ruprecht Karls Univ Heidelber, Organ Chem Inst, Neuenheimer Feld 270, D-69120 Heidelberg, Germany
[2] KAU, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 14期
关键词：
anilines; gold catalysis; heterocycles; quinolones; ynamides; NITRIC-OXIDE SYNTHASE; QUINOLINE DERIVATIVES; CLEAVING ENZYME; RECENT PROGRESS; INHIBITORS; CARBENES; CYCLIZATION; ANTAGONISTS; LIGANDS; POTENT;
D O I：
10.1002/adsc.201800341
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A gold-catalyzed intermolecular [4+2] annulation of easily accessible 2-ethynylanilines with ynamides offers a highly region-selective, modular, efficient, and atom-economical strategy for the synthesis of substituted 2-aminoquinolines in up to 93% yield.
引用
收藏
页码：2720 / 2726
页数：7
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