Enantio- and diastereoselective synthesis of anti-α-bromo-α-fluoro-β-hydroxycarboxylates

被引：0
|
作者：
Iseki, K [1 ]
Kuroki, Y [1 ]
Kobayashi, Y [1 ]
机构：
[1] Daikin Ind Ltd, MEC Lab, Tsukuba, Ibaraki 305, Japan
来源：
SYNLETT | 1998年 / 04期
关键词：
catalytic asymmetric aldol reaction; bromofluoroketene silyl acetal; chiral fluoroorganic compounds; alpha-bromo-alpha-fluoro-beta-hydroxy esters; aldehyde;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of aldehydes with bromofluoroketene silyl acetal 1 in the presence of 20 mol% chiral Lewis acid 2 proceeds with enantio- and diastereoselectivities at -20 degrees C to afford optically active anti-alpha-bromo-alpha-fluoro-beta-hydroxy esters 3a-f (up to 89:11 anti:syn, up to 93% ee).
引用
收藏
页码：437 / +
页数：4
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