Efficacy of BCG vaccine in animal models of neurological disorders

被引：7
|
作者：
Cossu, Davide [1 ,2 ]
Ruberto, Stefano [1 ]
Yokoyama, Kazumasa [2 ]
Hattori, Nobutaka [2 ]
Sechi, Leonardo A. [1 ,3 ]
机构：
[1] Univ Sassari, Dept Biomed Sci, Div Microbiol & Virol, I-09100 Sassari, Italy
[2] Juntendo Univ, Dept Neurol, Tokyo 1138431, Japan
[3] AOU Sassari, SC Microbiol, Sassari, Italy
来源：
VACCINE | 2022年 / 40卷 / 03期
关键词：
BCG; Neuroprotection; Experimental auto immune; encephalomyelitis; Alzheimer's disease; Parkinson's disease; Neurocognition; BACILLUS-CALMETTE-GUERIN; CENTRAL-NERVOUS-SYSTEM; T-CELLS; APP/PS1; MICE; MOUSE MODEL; INFECTION; IMMUNIZATION; COMBINATION; SUPPRESSION; DEPRESSION;
D O I：
10.1016/j.vaccine.2021.12.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Bacillus Calmette-Guerin (BCG) vaccine can modulate the immune response via antigen-specific immune response, but also it can confer nonspecific protection and therapeutic benefits in several neurological conditions through different heterologous effects of vaccination. However, the precise mechanism of action of BCG remains unclear. In this review, different mechanisms underlying BCG-mediated immunity will be explained in animal models that reflects characteristic feature of neuroinflammatory and neurodegenerative disorders such as multiple sclerosis, Alzheimer's and Parkinson's diseases. Furthermore, evidence for a beneficial effect of the BCG on neuropsychiatric disorders, will be also discussed. (C) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页码：432 / 436
页数：5
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