Efficacy of BCG vaccine in animal models of neurological disorders

被引：7
|
作者：
Cossu, Davide [1 ,2 ]
Ruberto, Stefano [1 ]
Yokoyama, Kazumasa [2 ]
Hattori, Nobutaka [2 ]
Sechi, Leonardo A. [1 ,3 ]
机构：
[1] Univ Sassari, Dept Biomed Sci, Div Microbiol & Virol, I-09100 Sassari, Italy
[2] Juntendo Univ, Dept Neurol, Tokyo 1138431, Japan
[3] AOU Sassari, SC Microbiol, Sassari, Italy
来源：
VACCINE | 2022年 / 40卷 / 03期
关键词：
BCG; Neuroprotection; Experimental auto immune; encephalomyelitis; Alzheimer's disease; Parkinson's disease; Neurocognition; BACILLUS-CALMETTE-GUERIN; CENTRAL-NERVOUS-SYSTEM; T-CELLS; APP/PS1; MICE; MOUSE MODEL; INFECTION; IMMUNIZATION; COMBINATION; SUPPRESSION; DEPRESSION;
D O I：
10.1016/j.vaccine.2021.12.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Bacillus Calmette-Guerin (BCG) vaccine can modulate the immune response via antigen-specific immune response, but also it can confer nonspecific protection and therapeutic benefits in several neurological conditions through different heterologous effects of vaccination. However, the precise mechanism of action of BCG remains unclear. In this review, different mechanisms underlying BCG-mediated immunity will be explained in animal models that reflects characteristic feature of neuroinflammatory and neurodegenerative disorders such as multiple sclerosis, Alzheimer's and Parkinson's diseases. Furthermore, evidence for a beneficial effect of the BCG on neuropsychiatric disorders, will be also discussed. (C) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页码：432 / 436
页数：5
相关论文
共 50 条
  • [1] Animal models of neurological disorders
    Marie-Françoise Chesselet
    [J]. NeuroRX, 2005, 2 (3): : 395 - 395
  • [2] Animal Models of Neurological Disorders
    Marie-Francoise Chesselet
    S. Thomas Carmichael
    [J]. Neurotherapeutics, 2012, 9 : 241 - 244
  • [3] Animal Models of Neurological Disorders
    Chesselet, Marie-Francoise
    Carmichael, S. Thomas
    [J]. NEUROTHERAPEUTICS, 2012, 9 (02) : 241 - 244
  • [4] Animal models for studies of genetic neurological disorders
    Suzuki, K
    [J]. CHALLENGES FOR NEUROSCIENCE IN THE 21ST CENTURY, 2000, (22): : 267 - 283
  • [5] A New Look at Animal Models of Neurological Disorders
    Marie-Françoise Chesselet
    [J]. Neurotherapeutics, 2023, 20 (1) : 1 - 2
  • [6] A New Look at Animal Models of Neurological Disorders
    Chesselet, Marie-Francoise
    [J]. NEUROTHERAPEUTICS, 2023, 20 (01) : 1 - 2
  • [7] EFFICACY OF BCG VACCINE
    BELLIN, E
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (10): : 765 - 765
  • [8] Large Animal Models of Neurological Disorders for Gene Therapy
    Gagliardi, Christine
    Bunnell, Bruce A.
    [J]. ILAR JOURNAL, 2009, 50 (02) : 128 - 143
  • [9] Animal Models of Neurological Disorders: Where Are We Now?
    Panthi, Sandesh
    Ekker, Marc
    [J]. BIOMEDICINES, 2023, 11 (05)
  • [10] Therapeutic Effects of Progesterone in Animal Models of Neurological Disorders
    De Nicola, Alejandro F.
    Coronel, Florencia
    Garay, Laura I.
    Gargiulo-Monachelli, Gisella
    Gonzalez Deniselle, Maria Claudia
    Gonzalez, Susana L.
    Labombarda, Florencia
    Meyer, Maria
    Guennoun, Rachida
    Schumacher, Michael
    [J]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2013, 12 (08) : 1205 - 1218
12345